NZB和NZB×NZW F1杂交小鼠中，B淋巴细胞将聚集的人丙种球蛋白（HGG）转运至生发中心存在缺陷。
A defect of B-lymphocyte transport of aggregated HGG into germinal centres in NZB and NZB x NZW F 1 hybrid mice.
作者信息
De Jesus D G, Holborow E J, Brown J C
出版信息
Clin Exp Immunol. 1972 Aug;11(4):507-22.
Previous experiments have shown (i) that the localization of intravenously injected heat aggregated human γ-globulin (HGG) in the germinal centres of normal mice provides a model for studying the natural uptake of circulating immune complexes in these areas, and (ii) that the aggregated HGG is carried into germinal centres by lymphocytes which have receptors for altered γ-globlin. Evidence from thymus-cell depletion experiments is now presented which suggests that the lymphocytes concerned are bone-marrow-derived B cells. Defective localization was found in NZB and NZB × NZW F hybrids at different ages and the onset of the autoimmunity and the appearance of histological abnormalities in the spleen. As disease develops it progresses to a complete inability to localize complexes in germinal centres. It is concluded that a functional defect of the bone marrow-derived lymphocyte population exists in these mice.
先前的实验表明
（i）静脉注射热聚集人γ球蛋白（HGG）在正常小鼠生发中心的定位为研究这些区域循环免疫复合物的自然摄取提供了一个模型；（ii）聚集的HGG由具有改变的γ球蛋白受体的淋巴细胞带入生发中心。现在呈现的来自胸腺细胞耗竭实验的证据表明相关淋巴细胞是骨髓来源的B细胞。在不同年龄的NZB和NZB×NZW F1杂种小鼠中发现定位缺陷，以及自身免疫的发作和脾脏组织学异常的出现。随着疾病发展，其进展为完全无法在生发中心定位复合物。得出的结论是这些小鼠中存在骨髓来源淋巴细胞群体的功能缺陷。
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