National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Guangdong Medical Laboratory Animal Center, Foshan 528248, China.
Genes (Basel). 2022 Nov 1;13(11):1998. doi: 10.3390/genes13111998.
Hypertension is an independent risk factor for atherosclerosis. However, few models of hypertensive atherosclerosis have been established in medical research. In this study, we crossed the knockout (-KO; ) atherosclerotic mouse model with the knockout (-KO; ) hypertensive mouse model to establish an double knockout (-KO; ) hypertensive atherosclerosis mouse model. We found that mice reproduced normally, had a blood pressure of 133.00 ± 3.85 mmHg, and developed hypertensive fundus retinopathy and hypertensive nephropathy. In addition, serum total cholesterol (TC) and low-density lipoprotein (LDL) levels in the blood were abnormally elevated, steatosis was observed in the liver cells, and atherosclerotic lesions were observed in the aortic vessels in adult mice. In conclusion, adult mice are a satisfactory model of hypertension and atherosclerosis and can be utilized for studies on cardiovascular diseases.
高血压是动脉粥样硬化的独立危险因素。然而，医学研究中建立的高血压动脉粥样硬化模型较少。在这项研究中，我们将 基因敲除（-/-；）动脉粥样硬化小鼠模型与 基因敲除（-/-；）高血压小鼠模型杂交，建立了 双基因敲除（-/-；）高血压动脉粥样硬化小鼠模型。我们发现 小鼠正常繁殖，血压为 133.00 ± 3.85mmHg，并出现高血压眼底视网膜病变和高血压肾病。此外， 成年小鼠的血液总胆固醇（TC）和低密度脂蛋白（LDL）水平异常升高，肝细胞脂肪变性，主动脉血管出现动脉粥样硬化病变。综上所述， 成年小鼠是一种满意的高血压和动脉粥样硬化模型，可用于心血管疾病的研究。
