CRISPR/Cas9 基因组编辑技术及其在胃癌中的潜在临床应用。
CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer.
机构信息
Discipline of Genetics, Department of Morphology and Genetics, Federal University of São Paulo, Rua Botucatu, 740, São Paulo 04023900, Brazil.
Discipline of Gastroenterology, Department of Medicine, Federal University of São Paulo, Rua Loefgreen, 1726, São Paulo 04040002, Brazil.
出版信息
Genes (Basel). 2022 Nov 4;13(11):2029. doi: 10.3390/genes13112029.
Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy and chemotherapy, they are extremely aggressive and limit the quality of life of these patients. CRISPR/Cas9 is a tool that allows gene editing and has been used to explore the functions of genes related to gastric cancer, in addition to being used in the treatment of this neoplasm, greatly increasing our understanding of cancer genomics. In this mini-review, we seek the current status of the CRISPR/Cas9 gene-editing technology in gastric cancer research and clinical research.
胃癌因其在全球范围内的高发病率和死亡率而成为临床和基础研究的课题。由于诊断发生在晚期，以及经典的治疗方法如胃切除术和化疗，它们极具侵袭性，限制了这些患者的生活质量。CRISPR/Cas9 是一种允许基因编辑的工具，已被用于探索与胃癌相关的基因的功能，此外还被用于治疗这种肿瘤，极大地增加了我们对癌症基因组学的理解。在这篇迷你综述中，我们寻求 CRISPR/Cas9 基因编辑技术在胃癌研究和临床研究中的现状。
Zotero 插件