Department of Pharmacology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.
Genes (Basel). 2022 Nov 6;13(11):2046. doi: 10.3390/genes13112046.
Genetic factors may predispose persons to decreased pain excitability. One of the interesting modulators affecting pain perception may be polymorphisms of the cannabinoid receptor type 1 () gene. In this study, we examined the association between three-nucleotide repeats (AAT) polymorphism located in the 3'UTR non-translational region of and the patient's quality of life after total hip arthroplasty. Our study examined the degree of pain sensation, hip function, and the patient's performance at defined intervals after elective hip replacement due to degenerative changes. The study included 198 patients (128 women and 70 men). The average age was 67 years. PCR genotyping assay was used to identify the (AAT)n triplet repeat polymorphism in the gene. The (AAT)n repeat number was determined by sequencing using a standard sequencing protocol. Our study found no statistically significant association between the degree of pain, hip function, and the change in the degree of disability and the (AAT)n polymorphism in the gene, no statistically significant correlations between clinical symptoms, the patient's age, and the number of AAT repeats, no association between the length of the allele and the degree of pain, hip function, and the change in disability.
遗传因素可能使个体对疼痛兴奋性降低易感。影响疼痛感知的一个有趣的调节剂可能是大麻素受体 1 型（）基因的多态性。在这项研究中，我们研究了位于 3'UTR 非翻译区的三核苷酸重复（AAT）多态性与全髋关节置换术后患者生活质量之间的关系。我们的研究检查了因退行性改变而选择性髋关节置换术后患者疼痛感知、髋关节功能和患者表现的程度，在特定的时间间隔进行。该研究包括 198 名患者（128 名女性和 70 名男性）。平均年龄为 67 岁。PCR 基因分型检测用于鉴定 基因中的（AAT）n 三核苷酸重复多态性。（AAT）n 重复数通过使用标准测序方案进行测序来确定。我们的研究没有发现（AAT）n 基因多态性与疼痛程度、髋关节功能和残疾程度变化之间存在统计学显著关联，也没有发现临床症状、患者年龄和 AAT 重复数之间存在统计学显著相关性，等位基因长度与疼痛程度、髋关节功能和残疾程度变化之间也没有关联。
