Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
Int J Environ Res Public Health. 2022 Oct 23;19(21):13785. doi: 10.3390/ijerph192113785.
Pulse pressure (PP) is the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), and an independent predictor of cardiovascular risk. Previous research suggests, with different conclusions, that exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) could affect blood pressure (BP). We conducted a cross-sectional study to determine the association of dioxin exposure with PP in early pregnancy. A total of 305 pregnant women in early pregnancy in Yingcheng, China, recruited from May 2018 to February 2021, were included in this study. We measured 17 congeners of PCDD/Fs in maternal serum via high-resolution gas chromatography tandem high-resolution mass spectrometry. A generalized linear regression model was used to analyze the influencing factors of dioxin exposure and their relationships with PP. The levels of total PCDD/Fs (∑PCDD/Fs) ranged from 163.52 pg/g lipid to 1,513,949.52 pg/g lipid, with a mean of 10,474.22 pg/g lipid. The mean toxicity equivalent (TEQ) of total PCDD/Fs (∑TEQ-PCDD/Fs) was 42.03 pg/g lipid. The ratio of tetrachlorinated to octa-chlorinated congeners in maternal serum was enriched with an increasing number of chlorines. Pregnant women with college and above education had higher concentrations of ∑PCDD/Fs than those with education levels of junior high school and below (β = 0.34, 95% CI: 0.01, 0.67). The adjusted model for ∑TEQ-PCDD/Fs was significantly and negatively associated with PP (β = -1.79, 95% CI: -2.91, -0.68). High levels of dioxins were found in this area, and exposure to dioxins may affect the PP of women in early pregnancy, with health risks.
脉搏压（PP）是收缩压（SBP）和舒张压（DBP）之间的差异，是心血管风险的独立预测因子。先前的研究表明，多氯二苯并对二恶英和多氯二苯并呋喃（PCDD/Fs）的暴露可能会影响血压（BP），但结论不一。我们进行了一项横断面研究，以确定妊娠早期二恶英暴露与 PP 的关系。本研究共纳入中国应城 305 名妊娠早期孕妇，于 2018 年 5 月至 2021 年 2 月招募。通过高分辨气相色谱串联高分辨质谱法测量了母体血清中 17 种 PCDD/Fs 同系物。采用广义线性回归模型分析了二恶英暴露的影响因素及其与 PP 的关系。总 PCDD/Fs（∑PCDD/Fs）水平范围为 163.52 pg/g 脂质至 1,513,949.52 pg/g 脂质，平均为 10,474.22 pg/g 脂质。总 PCDD/Fs（∑TEQ-PCDD/Fs）的毒性当量（TEQ）平均值为 42.03 pg/g 脂质。母体血清中四氯代至八氯代同系物的比例随氯原子数的增加而富集。与初中及以下学历的孕妇相比，具有大专及以上学历的孕妇∑PCDD/Fs 浓度更高（β=0.34，95%CI：0.01，0.67）。∑TEQ-PCDD/Fs 的调整模型与 PP 呈显著负相关（β=-1.79，95%CI：-2.91，-0.68）。该地区发现高水平的二恶英，二恶英暴露可能会影响妊娠早期妇女的 PP，存在健康风险。
