台湾暴露区中二噁英与代谢综合征的年龄和性别关联。

Association Between Dioxin and Metabolic Syndrome by Age and Sex in an Endemic Area of Exposure in Taiwan.

机构信息

From the aDepartment of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; bTainan Science Park Clinic, Chi-Mei Medical Center, Tainan 744, Taiwan; cResearch Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan 704, Taiwan; dDepartment of Occupational and Environmental Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; eDepartment of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan; and fOccupational Safety, Health, and Medicine Research Center, National Cheng Kung University, Tainan 704, Taiwan.

出版信息

Epidemiology. 2017 Oct;28 Suppl 1:S82-S88. doi: 10.1097/EDE.0000000000000697.

DOI:10.1097/EDE.0000000000000697

PMID:29028680

Abstract

BACKGROUND

Some of the effects of dioxins seem to be different between men and women, and exposures starting at an early age seem to have more prominent effects. Therefore, we conducted a study in Taiwan to evaluate the associations between exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and metabolic syndrome (MetS) starting at different ages in both sexes.

METHODS

We recruited participants from an area where residents were exposed to PCDD/Fs released from a factory and defined serum PCDD/Fs levels ≥20 pg WHO98-TEQDF/g lipid as high dioxin levels. MetS was defined as meeting three of the following criteria: fasting glucose ≥100 mg/dl or under treatment for diabetes, waist circumference ≥90 cm in men or ≥80 cm in women, triglycerides ≥150 mg/dl or under treatment for elevated triglycerides, high-density lipoprotein <40 mg/dl in men or <50 mg/dl in women, and blood pressures ≥130/85 mmHg or under treatment for hypertension.

RESULTS

Of the 2758 participants, 785 patients with MetS were identified, and we observed positive associations between a high dioxin level and MetS. After adjusting for sex, age, and age at starting exposure, we found that a high dioxin level was an independent predictor for MetS (adjusted odds ratio =1.38; 95% confidence interval = 1.11, 1.72). When we stratified the participants by gender, we found that a high dioxin level remained an independent predictor of MetS in men, but not in women, regardless of the age at starting exposure.

CONCLUSIONS

Exposure to PCDD/Fs was associated with MetS in men, independent of age and age at starting exposure.

摘要

背景

二噁英的一些影响似乎在男性和女性之间存在差异，并且早期暴露似乎会产生更显著的影响。因此，我们在台湾进行了一项研究，评估男性和女性在不同年龄段暴露于多氯二苯并对二噁英和二苯并呋喃（PCDD/Fs）与代谢综合征（MetS）之间的关联。

方法

我们从一个地区招募了参与者，该地区的居民受到了一家工厂排放的 PCDD/Fs 的暴露，并将血清 PCDD/Fs 水平≥20 pg WHO98-TEQDF/g 脂质定义为高水平二噁英。代谢综合征定义为满足以下三个标准中的三个：空腹血糖≥100mg/dl 或正在接受糖尿病治疗、男性腰围≥90cm 或女性腰围≥80cm、甘油三酯≥150mg/dl 或正在接受高甘油三酯治疗、男性高密度脂蛋白<40mg/dl 或女性高密度脂蛋白<50mg/dl 和血压≥130/85mmHg 或正在接受高血压治疗。

结果

在 2758 名参与者中，有 785 名患者被诊断为代谢综合征，我们观察到高水平二噁英与代谢综合征之间存在正相关关系。在调整了性别、年龄和开始暴露的年龄后，我们发现高水平二噁英是代谢综合征的独立预测因子（调整后的优势比=1.38；95%置信区间=1.11，1.72）。当我们按性别对参与者进行分层时，我们发现无论开始暴露的年龄如何，高水平二噁英仍然是男性代谢综合征的独立预测因子，但不是女性。