Department of Psychology, Texas Tech University, Lubbock, TX 79409, USA.
Department of Psychology, University of Alabama, 348 Gordon Palmer Hall, Box 870348, Tuscaloosa, AL 35487, USA.
Int J Environ Res Public Health. 2022 Oct 28;19(21):14032. doi: 10.3390/ijerph192114032.
Growing up in a family environment characterized by neglectful parenting, overt conflict, and unsupportive relationships is associated with poor health in adulthood. A risky early family environment may also be associated with obesity in adulthood, likely through the activation of the HPA axis. Likewise, the GABAergic (gamma-aminobutyric acid) T>C single nucleotide polymorphism in the 1519 nucleotide position of the receptor subunit gene has been associated with a predisposition to a higher body mass index and a larger waist circumference. Participants (n = 213, M = 30.13 years, SD = 10.85; 57.7% men) from the Pittsburgh Cold Study 3 completed a demographic questionnaire, the Risky Families Questionnaire (RFQ) and had their height, weight, and waist circumference measured during a physical exam. Participant DNA was recovered from buccal swabs and genotyped for the various allelic types of the SNP according to published protocols. In secondary data analyses, we tested the hypothesis that early family environment and would be positively associated with body mass index and waist circumference. We also examined diurnal cortisol as a mechanism linking both early risky family environment and to metabolic outcomes. The findings provide evidence that a risky early family environment may exert more influence than genetic predisposition when determining the indices of metabolic health in adulthood.
在一个忽视型育儿、公开冲突和缺乏支持的关系的家庭环境中成长与成年后的健康状况不佳有关。风险较高的早期家庭环境也可能与成年期肥胖有关，这可能是通过激活 HPA 轴实现的。同样， 受体亚基基因 1519 核苷酸位置的 GABA 能（γ-氨基丁酸）T>C 单核苷酸多态性与较高的体重指数和更大的腰围有关。匹兹堡寒冷研究 3 的 213 名参与者（M = 30.13 岁，SD = 10.85；57.7%为男性）完成了一份人口统计问卷、风险家庭问卷（RFQ），并在体检期间测量了身高、体重和腰围。参与者的 DNA 从口腔拭子中提取，并根据已发表的方案对 SNP 的各种等位基因类型进行基因分型。在二次数据分析中，我们检验了以下假设：早期家庭环境和 会与体重指数和腰围呈正相关。我们还研究了昼夜皮质醇作为将早期风险家庭环境和 与代谢结果联系起来的机制。研究结果表明，在决定成年期代谢健康指标时，风险较高的早期家庭环境可能比遗传易感性发挥更大的作用。
