Heart Center, Kaplan Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Rehovot 7661041, Israel.
Research Authority, Kaplan Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Rehovot 7661041, Israel.
Int J Mol Sci. 2022 Oct 28;23(21):13121. doi: 10.3390/ijms232113121.
Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) is a membrane receptor in myeloid cells that mediates cellular phagocytosis and inflammation. TREM2 and its soluble extracellular domain are clearly implicated in neuroinflammation and neurodegeneration. sTREM2 is also expressed in atherosclerotic macrophages. We hypothesized that sTREM2 would predict cardiovascular mortality in patients with established coronary atherosclerosis (CAD). Consecutive patients undergoing coronary angiography with the establishment of the diagnosis of CAD ( = 230) and without CAD ( = 53) were tested for their baseline serum sTREM2 levels. All patients were followed up for 84 months or until death occurred. sTREM2 correlated with age; however, no association was found between sTREM2 and the number of atherosclerotic vessels involved ( = 0.642). After 84 months of follow-up, 68 out of the 230 CAD patients had died. After adjusting for age and other risk factors, the adjusted hazard ratio for the highest quartile of sTREM2 was 2.37 (95% confidence interval 1.17-4.83) for death. In patients with established CAD, serum sTREM2 appears to predict cardiovascular death as a potential surrogate for plaque rupture. TREM2 and its soluble extracellular form might be implicated in the fate of the atherosclerotic plaque, but corroboration within larger studies is needed.
髓样细胞表达触发受体 2（TREM2）是髓样细胞中的一种膜受体，介导细胞吞噬和炎症反应。TREM2 及其可溶性细胞外结构域明显与神经炎症和神经退行性变有关。sTREM2 也在动脉粥样硬化的巨噬细胞中表达。我们假设 sTREM2 可预测已确诊的冠状动脉粥样硬化（CAD）患者的心血管死亡率。连续接受冠状动脉造影并确诊 CAD（=230 例）和无 CAD（=53 例）的患者检测其基线血清 sTREM2 水平。所有患者均随访 84 个月或直至死亡。sTREM2 与年龄相关；然而，sTREM2 与受累的动脉粥样硬化血管数量之间无关联（=0.642）。随访 84 个月后，230 例 CAD 患者中有 68 例死亡。校正年龄和其他危险因素后，sTREM2 最高四分位数的校正风险比为 2.37（95%置信区间为 1.17-4.83）。在已确诊的 CAD 患者中，血清 sTREM2 似乎可预测心血管死亡，是斑块破裂的潜在替代标志物。TREM2 及其可溶性细胞外形式可能与动脉粥样硬化斑块的命运有关，但需要更大规模研究的证实。
