Atkinson R L, Greenway F L, Bray G A, Dahms W T, Molitch M E, Hamilton K, Rodin J
Int J Obes. 1977;1(2):113-20.
In a randomized double-blind trial, 60 obese patients were assigned in groups of 12 to five therapists. The patients for each therapist were then randomly assigned in groups of four to placebo or one of two preparations of mazindol. Ninety-three percent of the patients completed the nine weeks of treatment. Weight loss averaged 1.1 lb per week and there was no advantage to pharmacological agents over placebo. However, there were significant differences between therapists. Weight loss by the patients assigned to physicians was no better than for those assigned to nonphysician personnel, but there were significant differences between individual nonphysician personnel. These findings support the concept that nonphysician personnel may be effective in treating many obese patients. In addition, we could not find a significant effect of either form of mazindol when compared to placebo.
在一项随机双盲试验中，60名肥胖患者被分成每组12人的小组，分配给5名治疗师。然后，为每位治疗师的患者再随机分成每组4人的小组，分别给予安慰剂或两种马吲哚制剂之一。93%的患者完成了为期9周的治疗。体重减轻平均每周1.1磅，与安慰剂相比，药物制剂并无优势。然而，治疗师之间存在显著差异。分配给医生的患者体重减轻情况并不比分配给非医生人员的患者好，但个别非医生人员之间存在显著差异。这些发现支持了非医生人员可能有效治疗许多肥胖患者的观点。此外，与安慰剂相比，我们未发现任何一种马吲哚制剂有显著效果。
