State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hospital of Chengdu University of Traditional Chinese Medicine, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Phytother Res. 2022 Jan;36(1):214-230. doi: 10.1002/ptr.7306. Epub 2021 Dec 22.
Polydatin (PD) is a natural single-crystal product that is primarily extracted from the traditional plant Polygonum cuspidatum Sieb. et Zucc. Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion-related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. In summary, we found that PD played a therapeutic role in a variety of diseases, primarily via five mechanisms: antioxidative effects, antiinflammatory effects, regulation of autophagy and apoptosis, maintenance of mitochondrial function, and lipid regulation.
虎杖苷（PD）是一种天然单晶产物，主要从传统植物虎杖中提取。早期研究表明 PD 具有多种生物活性。自 2014 年以来，PD 引起了越来越多的研究兴趣，但尚无综述全面总结新发现。其生物活性与药物开发之间存在巨大差距。有必要总结 PD 对当前疾病的药理作用的新发现。我们提出 PD 很可能在未来用于与心脏和大脑缺血/再灌注相关的疾病以及动脉粥样硬化。本工作根据疾病对这些新发现进行分类，并通过特定的作用机制总结 PD 的主要作用。总之，我们发现 PD 通过五种机制在多种疾病中发挥治疗作用：抗氧化作用、抗炎作用、自噬和凋亡调节、维持线粒体功能和脂质调节。
