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对二甲氧苯乙酸提取物对 BALB/c 小鼠变应性接触性皮炎样损伤的改善作用。

Ameliorative Effects of Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice.

机构信息

College of Pharmacy, Pusan National University, Busan 46241, Korea.

Natural Products Research Center, Korea Institute of Science and Technology, Gangneung 25451, Korea.

出版信息

Nutrients. 2022 Oct 27;14(21):4521. doi: 10.3390/nu14214521.

DOI:10.3390/nu14214521
PMID:36364783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9654989/
Abstract

The genus has been traditionally used as a purgative, diuretic, stimulant, and psoriasis treatment. In this study, the anti-AD (atopic dermatitis) activities of the EtOH extract (DCE) were investigated in an oxazolone (OX)-induced mouse model of AD, and the anti-inflammatory effects of its active compounds were confirmed in PI-sensitized or IgE/DNP-BSA-sensitized RBL-2H3 cells. DCE improved the symptoms of OX-induced inflammatory dermatitis (swelling, erythema, and increased ear thickening) in OX-induced BALB/c mice ears and reduced epidermal thickness and mast cell infiltration. Eleven flavonoid compounds were isolated from DCE, and two compounds (7,8-dimethoxyflavone and 7,2'-dimethoxyflavone) significantly inhibited IL-4 overexpression in PI-induced RBL-2H3 cells and mast cell degranulation in IgE + DNP-BSA-induced RBL-2H3 cells. Our study indicates that DCE and two compounds (7,8-dimethoxyflavone and 7,2'-dimethoxyflavone) might effectively improve inflammatory and atopic skin symptoms.

摘要

该属植物传统上被用作泻药、利尿剂、兴奋剂和治疗银屑病。在这项研究中，研究了 的乙醇提取物 (DCE) 在氧化氮诱导的 AD 小鼠模型中的抗 AD（特应性皮炎）活性，并证实了其活性化合物在 PI 敏化或 IgE/DNP-BSA 敏化 RBL-2H3 细胞中的抗炎作用。DCE 改善了 OX 诱导的 BALB/c 小鼠耳部氧化氮诱导的炎症性皮炎（肿胀、红斑和耳增厚增加）的症状，并降低了表皮厚度和肥大细胞浸润。从 DCE 中分离出 11 种类黄酮化合物，两种化合物（7,8-二甲氧基黄酮和 7,2'-二甲氧基黄酮）显著抑制了 PI 诱导的 RBL-2H3 细胞中 IL-4 的过度表达和 IgE + DNP-BSA 诱导的 RBL-2H3 细胞中肥大细胞脱颗粒。我们的研究表明，DCE 和两种化合物（7,8-二甲氧基黄酮和 7,2'-二甲氧基黄酮）可能有效改善炎症和特应性皮肤症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/81ff3d1842d6/nutrients-14-04521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/bbc369de80c0/nutrients-14-04521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/0d6e9697181f/nutrients-14-04521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/c4f17acd95fe/nutrients-14-04521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/5d28c58da0db/nutrients-14-04521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/81ff3d1842d6/nutrients-14-04521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/bbc369de80c0/nutrients-14-04521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/0d6e9697181f/nutrients-14-04521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/c4f17acd95fe/nutrients-14-04521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/5d28c58da0db/nutrients-14-04521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d25/9654989/81ff3d1842d6/nutrients-14-04521-g005.jpg

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Biomed Pharmacother. 2021 Aug;140:111741. doi: 10.1016/j.biopha.2021.111741. Epub 2021 Jun 2.
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Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis.
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