人乳头瘤病毒感染是否会影响头颈部癌症患者营养障碍的发生频率和严重程度？

Does Human Papillomavirus Infection Influence the Frequency and Severity of Nutritional Disorders in Head and Neck Cancer?

机构信息

Department of Human Physiology of the Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland.

Laboratory of Body Composition Research of the Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland.

出版信息

Nutrients. 2022 Oct 27;14(21):4528. doi: 10.3390/nu14214528.

DOI:10.3390/nu14214528

PMID:36364788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9656707/

Abstract

BACKGROUND

About 87% of head and neck cancer (HNC) patients (mostly oropharyngeal cancer-OPC) are infected with human papillomavirus (HPV). Recent studies have demonstrated a significant correlation between HPV infection and nutritional disorders in HNC patients. Therefore, we formed a hypothesis that nutritional disorders or their severity in HNC patients may be associated with the occurrence of HPV infection due to known molecular differences in involved tissue. This literature review aimed to evaluate the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC patients.

MATERIALS AND METHODS

The PubMed database was used to search papers with the keywords "HPV", "HNC", and "nutritional disorders" in different variants and combinations.

CONCLUSIONS

The data available in the discussed papers indicate, among other things, that HPV-positive patients may be at higher risk of malnutrition, critical weight loss, and necessity for gastrostomy after radiotherapy or chemoradiotherapy (C-RT). It should be highlighted that despite some studies demonstrating positive results, currently available data regarding the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC remain limited and inconclusive, and thus further research on this issue is warranted.

摘要

背景

约 87%的头颈部癌症（HNC）患者（主要为口咽癌-OPC）感染了人乳头瘤病毒（HPV）。最近的研究表明 HPV 感染与 HNC 患者的营养障碍之间存在显著相关性。因此，我们提出了一个假设，即由于涉及组织中的已知分子差异，HNC 患者的营养障碍或其严重程度可能与 HPV 感染的发生有关。本文献综述旨在评估 HPV 感染对头颈部癌症患者营养障碍的发生和严重程度的影响。