Department of Human Physiology of the Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland.
Laboratory of Body Composition Research of the Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland.
Nutrients. 2022 Oct 27;14(21):4528. doi: 10.3390/nu14214528.
About 87% of head and neck cancer (HNC) patients (mostly oropharyngeal cancer-OPC) are infected with human papillomavirus (HPV). Recent studies have demonstrated a significant correlation between HPV infection and nutritional disorders in HNC patients. Therefore, we formed a hypothesis that nutritional disorders or their severity in HNC patients may be associated with the occurrence of HPV infection due to known molecular differences in involved tissue. This literature review aimed to evaluate the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC patients.
The PubMed database was used to search papers with the keywords "HPV", "HNC", and "nutritional disorders" in different variants and combinations.
The data available in the discussed papers indicate, among other things, that HPV-positive patients may be at higher risk of malnutrition, critical weight loss, and necessity for gastrostomy after radiotherapy or chemoradiotherapy (C-RT). It should be highlighted that despite some studies demonstrating positive results, currently available data regarding the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC remain limited and inconclusive, and thus further research on this issue is warranted.
约 87%的头颈部癌症（HNC）患者（主要为口咽癌-OPC）感染了人乳头瘤病毒（HPV）。最近的研究表明 HPV 感染与 HNC 患者的营养障碍之间存在显著相关性。因此，我们提出了一个假设，即由于涉及组织中的已知分子差异，HNC 患者的营养障碍或其严重程度可能与 HPV 感染的发生有关。本文献综述旨在评估 HPV 感染对头颈部癌症患者营养障碍的发生和严重程度的影响。
使用 PubMed 数据库，以 HPV、HNC 和营养障碍等不同变体和组合的关键词搜索文献。
所讨论的论文中的数据表明，HPV 阳性患者在接受放疗或放化疗（C-RT）后可能面临更高的营养不良、体重显著减轻和需要胃造口的风险。值得强调的是，尽管一些研究显示出阳性结果，但目前关于 HPV 感染对头颈部癌症患者营养障碍的发生和严重程度的影响的数据仍然有限且不确定，因此需要对此问题进行进一步研究。
