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两亲性嵌段共聚物：其结构以及作为药物递送载体自组装形成聚合物胶束和聚合物囊泡的过程

Amphiphilic Block Copolymers: Their Structures, and Self-Assembly to Polymeric Micelles and Polymersomes as Drug Delivery Vehicles.

作者信息

Kuperkar Ketan, Patel Dhruvi, Atanase Leonard Ionut, Bahadur Pratap

机构信息

Department of Chemistry, Sardar Vallabhbhai National Institute of Technology (SVNIT), Ichchhanath, Surat 395 007, Gujarat, India.

Faculty of Medical Dentistry, "Apollonia" University of Iasi, 700511 Iasi, Romania.

出版信息

Polymers (Basel). 2022 Nov 3;14(21):4702. doi: 10.3390/polym14214702.

DOI:10.3390/polym14214702
PMID:36365696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9657626/
Abstract

Self-assembly of amphiphilic block copolymers display a multiplicity of nanoscale periodic patterns proposed as a dominant tool for the 'bottom-up' fabrication of nanomaterials with different levels of ordering. The present review article focuses on the recent updates to the self-association of amphiphilic block copolymers in aqueous media into varied core-shell morphologies. We briefly describe the block copolymers, their types, microdomain formation in bulk and micellization in selective solvents. We also discuss the characteristic features of block copolymers nanoaggregates viz., polymer micelles (PMs) and polymersomes. Amphiphilic block copolymers (with a variety of hydrophobic blocks and hydrophilic blocks; often polyethylene oxide) self-assemble in water to micelles/niosomes similar to conventional nonionic surfactants with high drug loading capacity. Double hydrophilic block copolymers (DHBCs) made of neutral block-neutral block or neutral block-charged block can transform one block to become hydrophobic under the influence of a stimulus (physical/chemical/biological), and thus induced amphiphilicity and display self-assembly are discussed. Different kinds of polymer micelles (viz. shell and core-cross-linked, core-shell-corona, schizophrenic, crew cut, Janus) are presented in detail. Updates on polymerization-induced self-assembly (PISA) and crystallization-driven self-assembly (CDSA) are also provided. Polyion complexes (PICs) and polyion complex micelles (PICMs) are discussed. Applications of these block copolymeric micelles and polymersomes as nanocarriers in drug delivery systems are described.

摘要

两亲性嵌段共聚物的自组装呈现出多种纳米级周期性图案，这些图案被认为是“自下而上”制备具有不同有序程度纳米材料的主要工具。本文综述聚焦于两亲性嵌段共聚物在水性介质中自缔合形成各种核壳形态的最新进展。我们简要描述了嵌段共聚物、它们的类型、本体中的微区形成以及在选择性溶剂中的胶束化。我们还讨论了嵌段共聚物纳米聚集体的特征，即聚合物胶束（PMs）和聚合物囊泡。两亲性嵌段共聚物（具有多种疏水嵌段和亲水嵌段；通常是聚环氧乙烷）在水中自组装成胶束/非离子脂质体，类似于具有高载药能力的传统非离子表面活性剂。由中性嵌段 - 中性嵌段或中性嵌段 - 带电嵌段组成的双亲水嵌段共聚物（DHBCs）在刺激（物理/化学/生物）影响下可使一个嵌段变得疏水，从而诱导两亲性并表现出自组装，对此也进行了讨论。详细介绍了不同种类的聚合物胶束（即壳交联和核交联、核 - 壳 - 冠、精神分裂症型、平头型、两面神型）。还提供了聚合诱导自组装（PISA）和结晶驱动自组装（CDSA）的最新进展。讨论了聚离子复合物（PICs）和聚离子复合物胶束（PICMs）。描述了这些嵌段共聚物胶束和聚合物囊泡作为纳米载体在药物递送系统中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d8b115a54886/polymers-14-04702-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/4e1b1ee21042/polymers-14-04702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/dd4a3f95b650/polymers-14-04702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/b61ec85f7ef2/polymers-14-04702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/9f8bd31f02a5/polymers-14-04702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/0cb6e63b8d01/polymers-14-04702-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/c861645b403c/polymers-14-04702-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/c32feda32ea5/polymers-14-04702-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/bc08c3d06191/polymers-14-04702-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d5945cd7e405/polymers-14-04702-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d658b666475d/polymers-14-04702-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/3252be5b441d/polymers-14-04702-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/b8b538806ca1/polymers-14-04702-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d8b115a54886/polymers-14-04702-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/4e1b1ee21042/polymers-14-04702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/dd4a3f95b650/polymers-14-04702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/b61ec85f7ef2/polymers-14-04702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/9f8bd31f02a5/polymers-14-04702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/0cb6e63b8d01/polymers-14-04702-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/c861645b403c/polymers-14-04702-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/c32feda32ea5/polymers-14-04702-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/bc08c3d06191/polymers-14-04702-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d5945cd7e405/polymers-14-04702-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d658b666475d/polymers-14-04702-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/3252be5b441d/polymers-14-04702-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/b8b538806ca1/polymers-14-04702-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f3/9657626/d8b115a54886/polymers-14-04702-g013.jpg

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[1]
Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone).

Polymers (Basel). 2022-9-7

[2]
Drug-Loaded Polymeric Micelles Based on Smart Biocompatible Graft Copolymers with Potential Applications for the Treatment of Glaucoma.

Int J Mol Sci. 2022-8-19

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Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery.

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Polymers (Basel). 2022-1-20

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