School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Republic of Korea.
Biomater Sci. 2022 Sep 27;10(19):5369-5390. doi: 10.1039/d2bm00719c.
Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials. In particular, their hierarchical pore structures, variable morphologies, and tunable biological properties make them suitable as drug-delivery systems. In this review, the synthetic and post forming/control methods including templated methods, template-free methods, mechanical methods, electrospun methods, and 3D printing methods for controlling the hierarchical structures and morphologies of porous organic polymers are discussed, and the different methods affecting their specific surface areas, hierarchical structures, and unique morphologies are highlighted in detail. In addition, we discuss their applications in drug encapsulation and the development of stimuli (pH, heat, light, and dual-stimuli)-responsive materials, focusing on their use for targeted drug release and as therapeutic agents. Finally, we present an outlook concerning the research directions and applications of porous polymer-based drug delivery systems.
近年来，多孔有机聚合物因其在生物材料方面的应用而受到广泛关注。特别是，它们的分级孔结构、可变形的形态和可调节的生物特性使它们成为适合药物输送系统的材料。在这篇综述中，我们讨论了控制多孔有机聚合物的分级结构和形态的合成和后成型/控制方法，包括模板法、无模板法、机械法、静电纺丝法和 3D 打印法，并详细强调了不同方法对其比表面积、分级结构和独特形态的影响。此外，我们还讨论了它们在药物封装和刺激（pH、热、光和双刺激）响应材料中的应用，重点介绍了它们在靶向药物释放和作为治疗剂方面的应用。最后，我们对基于多孔聚合物的药物输送系统的研究方向和应用提出了展望。
