Hong Jing, Pan Bo, Jiang Hui-Juan, Zhang Qing-Mei, Xu Xiao-Wan, Jiang Han, Ye Jiang-E, Cui Yu, Yan Xiao-Jie, Zhai Xiao-Feng, Yu Qin
Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Integrative Oncology, Changhai Hospital, Naval Medical University, Shanghai, China.
J Med Virol. 2023 Jan;95(1):e28294. doi: 10.1002/jmv.28294. Epub 2022 Nov 18.
The global monkeypox outbreak in 2022 has severely affected the life and health of people. Currently, partial smallpox vaccines have been approved for monkeypox prevention. Considering the potential occupational health risks of monkeypox infection among healthcare workers (HCWs), this study explored the willingness of Chinese HCWs to receive the monkeypox vaccine and analyzed the factors influencing their decision. We conducted an online cross-sectional survey among HCWs of 10 Chinese hospitals from May 30th, 2022 to August 1st, 2022. Specifically, a self-report questionnaire was administered to evaluate the attitude and acceptance of HCWs toward the monkeypox vaccine, followed by a multivariate logistic regression analysis to determine the independent predictors of vaccination. The survey included 1032 participants, of whom 90.12% expressed their willingness for vaccination (vaccine hesitancy rate = 9.88%). Univariate analysis showed that 11 variables differed significantly between the vaccine acceptance and vaccine hesitancy groups. Multivariate logistic regression analysis demonstrated that the age of 30-40 years (odds ratio [OR] = 0.504, 95% confidence interval [CI]: 0.284-0.893, p = 0.019 vs. age of <30 years old), working in a secondary hospital (OR = 0.449, 95% CI: 0.249-0.808, p = 0.019 vs. working in a tertiary hospital), considering vaccination necessary for controlling monkeypox infection (OR = 4.135, 95% CI: 2.109-8.106, p < 0.001 vs. not considering it necessary), willingness to pay for the monkeypox vaccine (OR = 2.125, 95% CI: 1.206-3.745, p = 0.009 vs. no willingness to pay), considering implementation of mandatory vaccination necessary (OR = 1.990, 95% CI: 1.023-3.869, p = 0.043 vs. not considering it necessary), and recommending family members and friends to take the vaccine (OR = 13.847, 95% CI: 7.487-25.609, p < 0.001 vs. not recommending) were crucial independent predictors of the willingness to receive monkeypox-related vaccination. This study evaluated the acceptance and hesitancy rates of Chinese HCWs toward the monkeypox vaccine and found that the willingness to receive vaccination was mainly correlated to age, hospital level, and attitude toward vaccination. Therefore, to promote vaccine absorption, we recommend expanding publicity, formulating reasonable policies, and improving the recognition of vaccines.
2022年全球猴痘疫情严重影响了人们的生命健康。目前，部分天花疫苗已获批用于预防猴痘。考虑到医护人员感染猴痘的潜在职业健康风险，本研究探讨了中国医护人员接种猴痘疫苗的意愿，并分析了影响其决策的因素。2022年5月30日至8月1日，我们对中国10家医院的医护人员进行了一项在线横断面调查。具体而言，采用自填式问卷评估医护人员对猴痘疫苗的态度和接受程度，随后进行多因素logistic回归分析以确定接种疫苗的独立预测因素。该调查共纳入1032名参与者，其中90.12%表示愿意接种（疫苗犹豫率为9.88%）。单因素分析显示，疫苗接受组和疫苗犹豫组之间有11个变量存在显著差异。多因素logistic回归分析表明，30 - 40岁（比值比[OR]=0.504，95%置信区间[CI]：0.284 - 0.893，p = 0.019，与<30岁相比）、在二级医院工作（OR = 0.449，95% CI：0.249 - 0.808，p = 0.019，与在三级医院工作相比）、认为接种疫苗对控制猴痘感染有必要（OR = 4.135，95% CI：2.109 - 8.106，p < 0.001，与认为没必要相比）、愿意为猴痘疫苗付费（OR = 2.125，95% CI：1.206 - 3.745，p = 0.009，与不愿意付费相比）、认为实施强制接种有必要（OR = 1.990，95% CI：1.023 - 3.869，p = 0.043，与认为没必要相比）以及推荐家人和朋友接种疫苗（OR = 13.847，95% CI：7.487 - 25.609，p < 0.001，与不推荐相比）是接受猴痘相关疫苗接种意愿的关键独立预测因素。本研究评估了中国医护人员对猴痘疫苗的接受率和犹豫率，发现接种意愿主要与年龄、医院级别和对疫苗的态度相关。因此，为提高疫苗接种率，我们建议扩大宣传、制定合理政策并提高对疫苗的认知度。
