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[已撤回] 营养物质对1型人类嗜T淋巴细胞病毒阳性和阴性恶性T淋巴细胞中基质金属蛋白酶的影响。

[Retracted] Effects of nutrients on matrix metalloproteinases in human T‑lymphotropic virus type 1 positive and negative malignant T‑lymphocytes.

作者信息

Harakeh Steve, Abou-Khouzam Raefa, Damanhouri Ghazi A, Al-Hejin Ahmed, Kumosani Taha, Niedzwiecki Aleksandra, Rath Mathias, Barbour Elie, Diab-Assaf Mona, Azar Rania

机构信息

Special Infectious Agents unit, king fahd Medical research Center, king Abdulaziz university, kingdom of Saudi Arabia.

Molecular Tumor-genesis and Anticancer Pharmacology, EDST, Lebanese university, Hadath, Lebanon.

出版信息

Int J Oncol. 2023 Jan;62(1). doi: 10.3892/ijo.2022.5451. Epub 2022 Nov 11.

DOI:10.3892/ijo.2022.5451
PMID:36367176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9699721/
Abstract

Subsequently to the publication of the above article, a concerned reader drew to the attention of the Editorial Office and the authors that certain pairings of the GAPDH western blotting control bands in Fig. 4 appeared to be strikingly similar to adjacent pairings of bands within the same gel slices; moreover, data bands featured in the HuT‑2, C91‑PL and Jurkat zymography blots in Fig. 5 also appeared to be remarkably similar, both comparing the bands within a given gel slice (as in the case of the Jurkat cell experiment in Fig. 5) or comparing between gel slices (as in the case of the Hut‑2 cells compared with the C910PL cells in Fig. 5). The Editorial Office independently investigated these concerns, and reached the conclusion that the bands did appear strikingly similar; too similar for the appearance of the bands within these figures to have arisen by chance. Moreover, the application of a software analysis program revealed that certain of the data in Fig. 6 had also appeared in another paper published by several of the same authors in another journal at around the same time. As a result of this investigation, the Editor of has decided that this paper should be retracted from the journal on account of a lack of confidence in the authenticity of the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Oncology 45: 2159‑2166, 2014; DOI: 10.3892/ijo.2014.2638].

摘要

在上述文章发表之后,一位关注此事的读者提请编辑部和作者注意,图4中GAPDH蛋白质免疫印迹对照条带的某些配对与同一凝胶切片内相邻的条带配对惊人地相似;此外,图5中HuT-2、C91-PL和Jurkat酶谱印迹中的数据条带看起来也非常相似,无论是在给定凝胶切片内比较条带(如图5中Jurkat细胞实验的情况)还是在凝胶切片之间比较(如图5中Hut-2细胞与C910PL细胞比较的情况)。编辑部独立调查了这些问题,得出的结论是这些条带确实看起来惊人地相似;相似程度太高,以至于这些图中的条带不太可能是偶然出现的。此外,应用软件分析程序显示,图6中的某些数据也出现在同一批作者大约在同一时间在另一家期刊上发表的另一篇论文中。由于这项调查,《国际肿瘤学杂志》的编辑决定,鉴于对所呈现数据的真实性缺乏信心,应从该期刊撤回这篇论文。编辑部要求作者对这些问题作出解释,但未收到令人满意的答复。编辑就由此造成的不便向读者致歉。[《国际肿瘤学杂志》45: 2159 - 2166, 2014;DOI: 10.3892/ijo.2014.2638]

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