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[已撤回] Slug通过直接调控雌激素受体α信号通路促进癌症进展。

[Retracted] Slug contributes to cancer progression by direct regulation of ERα signaling pathway.

作者信息

Li Youqiang, Wu Yanyuan, Abbatiello Thomas C, Wu Warren L, Kim Ju Ri, Sarkissyan Marianna, Sarkissyan Suren, Chung Seyung S, Elshimali Yahya, Vadgama Jaydutt V

机构信息

Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

出版信息

Int J Oncol. 2024 Nov;65(5). doi: 10.3892/ijo.2024.5689. Epub 2024 Sep 20.

DOI:10.3892/ijo.2024.5689
PMID:39301628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11419408/
Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by concerned readers that β‑actin bands shown in Figs. 1, 2 and 4 were strikingly similar, where the experimental conditions reported in Fig. 4 differed from those in Figs. 1 and 2; moreover, the Slug protein bands featured in Figs. 4a and 5a were remarkably similar in spite of the different experimental conditions that were reported in the respective figure legends, and the shape of the vimentin protein bands in Fig. 5e bore a strong similarity to the Slug protein bands that were featured in Fig. 2c, in spite of the bands being of slightly different sizes and arranged in a different orientation.  Although the possibility of publishing a corrigendum was considered, software analysis of the highlighted bands performed independently by the Editorial Office demonstrated that the bands in question were likely to have been matching bands. Therefore, given the number of potential concerns that were identified with the assembly of various of the figures in this paper, the Editor of has decided not to proceed with a corrigendum, and has determined that the paper should instead be retracted from the Journal on account of an overall lack of confidence in the originally presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Oncology 46: 1461‑1472, 2015; DOI: 10.3892/ijo.2015.2878].

摘要

上述论文发表后,相关读者引起了编辑的注意,即图1、2和4中所示的β-肌动蛋白条带惊人地相似,而图4中报告的实验条件与图1和2中的不同;此外,尽管各自图注中报告的实验条件不同,但图4a和5a中的Slug蛋白条带非常相似,并且图5e中波形蛋白蛋白条带的形状与图2c中的Slug蛋白条带非常相似,尽管条带大小略有不同且排列方向不同。虽然考虑过发布勘误,但编辑办公室独立进行的对突出显示条带的软件分析表明,所讨论的条带可能是匹配条带。因此,鉴于本文中多个图的组装存在诸多潜在问题,编辑决定不发布勘误,并决定鉴于对原始呈现数据总体缺乏信心,应从该期刊撤回该论文。已要求作者对这些问题作出解释,但编辑办公室未收到令人满意的答复。编辑就由此造成的不便向读者致歉。[《国际肿瘤学杂志》46: 1461 - 1472, 2015;DOI: 10.3892/ijo.2015.2878]

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