Université Côte d'Azur, CNRS, Institut de Chimie de Nice, Parc Valrose, 06108, Nice cedex 2, France.
Alysophil SAS, Bio Parc, 850 bd Sébastien Brant, BP 30170, 67405, Illkirch, France.
Chempluschem. 2022 Nov;87(11):e202200227. doi: 10.1002/cplu.202200227.
In this Review, both the scientific literature and patents have been analysed to gather, examine and classify synthetic strategies developed to access spirocyclic molecules having olfactory properties of interest for the perfume industry. New structures have been reported at a steady state since 1961 with a particularly intense activity in the 80's. In the diversity of olfactory properties observed, spirocyclic molecules were found to be quite frequently woody, as well as fruity and ambery, among other tonalities. More recent data reflect the evolution of modern synthetic organic chemistry towards bioinspiration, enantioselective reactions, green and sustainable chemistry and biotechnology.
在这篇综述中，我们分析了科学文献和专利，以收集、检查和分类用于获得具有香水行业应用潜力的具有气味特性的螺环分子的合成策略。自 1961 年以来，新结构不断涌现，特别是在 80 年代非常活跃。在观察到的各种气味特性中，螺环分子经常具有木质、果香和琥珀香等其他调香。最近的数据反映了现代有机合成化学朝着生物启发、对映选择性反应、绿色和可持续化学以及生物技术的发展。
