Kleoff Merlin, Kiler Paul, Heretsch Philipp
Freie Universität Berlin, Institut für Chemie und Biochemie, Fabeckstr. 34-36, 14195 Berlin, Germany.
PK Perfumes, Menifee, California, United States of America.
Beilstein J Org Chem. 2022 Jun 27;18:754-768. doi: 10.3762/bjoc.18.76. eCollection 2022.
Continuous flow technology is a key technology for sustainable manufacturing with numerous applications for the synthesis of fine chemicals. In recent years, the preparation of odorants utilizing the advantages of flow reactors received growing attention. In this review, we give an overview of selected methods for the synthesis of odorants in flow, including heterogeneously catalyzed reactions, gas reactions, and photochemical C-H functionalization processes. After a brief introduction on types of odorants, the presented odorant syntheses are ordered according to the main odor families "fruity", "green", "marine", "floral", "spicy", "woody", "ambery", and "musky" and their use and importance for perfumery is briefly discussed.
连续流动技术是可持续制造的关键技术，在精细化学品合成中有众多应用。近年来，利用流动反应器的优势制备香料受到越来越多的关注。在本综述中，我们概述了流动体系中香料合成的选定方法，包括多相催化反应、气体反应和光化学C-H官能化过程。在对香料类型进行简要介绍之后，所展示的香料合成方法按照主要的香料类别“果香”“青香”“海洋香”“花香”“辛香”“木香”“龙涎香”和“麝香”进行排序，并简要讨论了它们在香水制造中的用途和重要性。
