Givaudan Schweiz AG, Fragrances S&T, Ingredients Research, Kemptpark 50, 8310, Kemptthal, Switzerland.
Angew Chem Int Ed Engl. 2020 Sep 14;59(38):16310-16344. doi: 10.1002/anie.202005719. Epub 2020 Jul 20.
This review is the sequel to the 2000 report on the recent advances in the chemistry of odorants and it summarizes the developments in fragrance chemistry over the past 20 years. Following the olfactory spectrum set out in that report, trendsetting so-called captive odorants (patent-protected ingredients unavailable to the market) are presented according to the main odor families: "fruity", "marine", "green", "floral", "spicy", "woody", "amber", and "musky". The design of odorants, their chemical synthesis, and their use in modern perfumery are illustrated with prominent examples. Featured are new fruity odorants that provide signature in the top note, as well as precursor technology. In the green domain, focus is on leafy notes and green pear. New benzodioxepines and benzodioxoles have modernized the marine family and required a revision of the existing olfactophore models. The replacement of Lilial and Lyral kept the industry busy in the floral domain with a plethora of new "muguets". There was continued activity in the domain of rose odorants, especially in the area of rose ketones. Biotechnology became significant, for example, with Clearwood and Ambrofix, and the principal odorants of vetiver oil in the woody family have been found. Fourth and fifth families of musk odorants were also discovered and populated. Thus, new avenues for further explorations into fragrance chemistry have been opened.
这篇综述是对 2000 年关于气味剂化学近期进展报告的续篇，它总结了过去 20 年来香料化学的发展。按照该报告中提出的嗅觉光谱，根据主要气味家族，呈现了开创性的所谓“封闭气味剂”（受专利保护、无法进入市场的成分）：“果香”、“海洋”、“绿色”、“花香”、“辛香”、“木香”、“琥珀”和“麝香”。用突出的例子说明了气味剂的设计、化学合成及其在现代香水业中的应用。特色是提供前调特征的新型果香气味剂，以及前体技术。在绿色领域，重点是叶香调与青梨。新型苯并二氧杂环庚烯和苯并二氧杂环戊烯使海洋家族现代化，并要求对现有的嗅球模型进行修正。替代 Lilial 和 Lyral 使“铃兰”花香素成为花卉调香领域的热门话题，大量的新型“铃兰”素层出不穷。玫瑰香味剂领域也持续活跃，特别是在玫瑰酮领域。生物技术变得重要，例如 Clearwood 和 Ambrofix，在木质调香家族中发现了广藿香油的主要气味剂。还发现了第四和第五种麝香气味剂家族，并进行了填充。因此，为进一步探索香料化学开辟了新的途径。
