Gu Chongjuan, Zeng Xiaoqin, Shi Quan, Xiao Qing, He Yaojuan
Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Pathology department, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Gynecol Endocrinol. 2022 Nov;38(11):1014-1016. doi: 10.1080/09513590.2022.2143491. Epub 2022 Nov 11.
To present the clinicopathologic findings of the second case of androgen-secreting adult granulosa cell tumor (AGCT) in a woman with polycystic ovary syndrome (PCOS) and discuss in the light of the literature. Description of a case and discussion of the literature. A patient with oligomenorrhea, amenorrhea and hirsutism who was diagnosed as PCOS and treated by oral contraceptive for three years, then left ovarian solid and liquid mass was found and pathologically confirmed to be androgen-secreting AGCT after left oophorectomy. She got regular menstrual cycle and gave birth naturally, but clinical features of PCOS reappeared after breastfeeding. Androgen-secreting AGCT and PCOS have similar clinical features of hyperandrogenism, it is difficult to diagnose androgen-secreting AGCT when both diseases occur in the same patient. If the size of cystic mass in androgen-secreting AGCT is too small to differentiate from PCOM on imaging, pathological examination after surgery may be the only way to find the disease.
介绍一名患有多囊卵巢综合征（PCOS）的女性中第二例分泌雄激素的成人颗粒细胞瘤（AGCT）的临床病理结果，并结合文献进行讨论。病例描述与文献讨论。一名患有月经过少、闭经和多毛症的患者，被诊断为PCOS并接受口服避孕药治疗三年，随后发现左侧卵巢有实性和液性肿块，左侧卵巢切除术后病理证实为分泌雄激素的AGCT。她月经周期恢复正常并自然分娩，但母乳喂养后PCOS的临床特征再次出现。分泌雄激素的AGCT和PCOS具有相似的高雄激素血症临床特征，当两种疾病发生在同一患者身上时，很难诊断出分泌雄激素的AGCT。如果分泌雄激素的AGCT中囊性肿块的大小太小，在影像学上无法与多囊卵巢（PCOM）区分开来，手术后进行病理检查可能是发现该疾病的唯一方法。
