Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, 02-106 Warsaw, Poland.
Biomater Sci. 2022 Dec 20;11(1):37-61. doi: 10.1039/d2bm01513g.
The electrospinning method has been widely used to produce nano/micro fibers for various applications. As a drug delivery system, electrospun fibers display many advantages such as controlled drug delivery kinetics and the ability to deliver drugs locally. A drug delivery system improves delivery efficiency and reduces possible toxic effects. In particular, multiaxial fibers consisting of two or more fluid components have drawn attention for the simultaneous administration of multiple therapeutic agents for sustained delivery and effective treatment. This review discusses recently studied multi-compartment electrospun fibers, including side-by-side (Janus) and axially symmetric fibers - coaxial and triaxial - from the perspective of multi-drug incorporation. It begins with an overview of conventional uniaxial single-fluid electrospinning methods for drug delivery applications, then highlights the advantages of multi-compartment fibers for multi-substance loading/delivery and the advances in triaxial fibers that seem to be promising from the perspective of challenges for dressings and tissue regeneration. Furthermore, drug release mechanisms and kinetics are discussed in the controlled delivery of multiple therapeutics in fibers. In the conclusion, current biomedical applications of multi-drug delivery systems in selected applications and future perspectives are presented.
静电纺丝方法已广泛用于生产用于各种应用的纳米/微米纤维。作为药物传递系统，静电纺丝纤维具有许多优点，例如控制药物传递动力学和局部递药的能力。药物传递系统提高了传递效率并降低了可能的毒性作用。特别是由两种或更多种流体成分组成的多轴纤维，由于能够同时给予多种治疗药物以进行持续释放和有效治疗，因此引起了人们的关注。本文从多药物掺入的角度讨论了最近研究的多隔室静电纺纤维，包括并列（Janus）和轴对称纤维-共轴和三轴-纤维。本文首先概述了用于药物传递应用的传统单轴单流体静电纺丝方法，然后强调了多隔室纤维在多物质负载/传递方面的优势，以及从敷料和组织再生角度来看似乎很有前途的三轴纤维的进展。此外，还讨论了纤维中多种治疗药物的控释机制和动力学。在结论中，介绍了多药物传递系统在选定应用中的当前生物医学应用和未来展望。
