中性粒细胞与淋巴细胞比值与咽癌预后：系统评价和荟萃分析。
Neutrophil-to-lymphocyte and hypopharyngeal cancer prognosis: System review and meta-analysis.
机构信息
Department of Otolaryngology - Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China.
School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China.
出版信息
Head Neck. 2023 Feb;45(2):492-502. doi: 10.1002/hed.27246. Epub 2022 Nov 11.
Several studies have reported the value of neutrophil-to-lymphocyte ratio (NLR) for the prognosis of hypopharyngeal cancer. However, contradictory findings have also been published. We aimed to clarify the effect of NLR on the prognosis of hypopharyngeal cancer through meta-analysis. Systematic search of PubMed and other database with study selection and data extraction. The combined hazard ratio (HR) and 95% confidence intervals (CI) were calculated using STATA, applying either a fixed-effects or random-effects model. Meta-regression, subgroup analysis, and sensitivity analysis were used to analyze sources of heterogeneity. Publication bias were also assessed. This meta-analysis included 2232 patients with hypopharyngeal cancer from seven studies. The combined HR (OS, HR = 1.80, 95CI%, 1.14-2.82; PFS, HR = 1.88, 95CI%, 1.26-2.79) suggested that high NLR was associated with poor overall survival (OS) and progression-free survival (PFS). Pretreatment NLR can be used as an effective serological indicator to assess the prognosis of patients with hypopharyngeal cancer.
多项研究报道了中性粒细胞与淋巴细胞比值（NLR）对下咽癌预后的价值。然而，也有相互矛盾的发现。我们旨在通过荟萃分析阐明 NLR 对下咽癌预后的影响。系统检索 PubMed 和其他数据库，进行研究选择和数据提取。使用 STATA 计算合并风险比（HR）和 95%置信区间（CI），应用固定效应或随机效应模型。采用亚组分析和敏感性分析来分析异质性来源。还评估了发表偏倚。这项荟萃分析纳入了来自 7 项研究的 2232 例下咽癌患者。合并 HR（OS，HR=1.80，95CI%，1.14-2.82；PFS，HR=1.88，95CI%，1.26-2.79）表明，高 NLR 与总体生存（OS）和无进展生存（PFS）较差相关。治疗前 NLR 可作为评估下咽癌患者预后的有效血清学指标。
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