Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Department of Research & Development, East China Institute of Digital Medical Engineering, Shangrao, 334000, China.
J Wound Care. 2022 Nov 2;31(11):930-940. doi: 10.12968/jowc.2022.31.11.930.
To evaluate the safety and effectiveness of polylactic acid/gelatin nanofibre membranes (PGNMs) in treating hard-to-heal lower extremity venous ulcer wounds.
In this prospective study, patients with venous leg ulcers (VLUs) were treated with PGNMs or standard of care. Wounds were assessed once a week until the wound was fully healed.
The treatment group was comprised of 10 patients with VLUs, aged between 47-64 years, with an average age of 56.58±6.19 years. The wounds were located in the lower leg and/or ankle. Average wound area was 8.91±13.57cm (range: 1.5-52.5cm). Average wound healing time was 18.75±16.36 days. Of the patients, nine (90%) rated their pain as lighter when removing the dressing, with an average pain value of 2.0±1.0 points. There was less secondary trauma to the wound surface, and less bleeding. At six months after the wound healing, the scar evaluation (using the Vancouver Scar Scale) result was 3.75±1.96 points.
In this study, the PGNMs were safe and effective in treating hard-to-heal lower extremity VLUs.
评估聚乳酸/明胶纳米纤维膜（PGNMs）治疗下肢慢性难愈性静脉溃疡创面的安全性和有效性。
本前瞻性研究纳入了接受 PGNMs 或标准治疗的静脉性下肢溃疡（VLUs）患者。每周评估一次伤口，直至完全愈合。
治疗组 10 例 VLUs 患者的年龄为 47-64 岁，平均年龄（±标准差）为 56.58±6.19 岁。溃疡位于小腿和/或踝部，平均创面面积为 8.91±13.57cm²（范围：1.5-52.5cm²）。平均愈合时间为 18.75±16.36 天。9 例（90%）患者在去除敷料时自述疼痛减轻，平均疼痛评分为 2.0±1.0 分。创面二次创伤更小，出血更少。愈合 6 个月后，温哥华瘢痕量表评估结果为 3.75±1.96 分。
本研究中，PGNMs 治疗下肢慢性难愈性 VLUs 安全且有效。
