Santiago-Olivares Carlos, Martínez-Alvarado Eber, Rivera-Toledo Evelyn
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.
Viral Immunol. 2023 Jan;36(1):3-12. doi: 10.1089/vim.2022.0135. Epub 2022 Nov 11.
Respiratory RNA viruses are a major cause of acute lower respiratory tract infections and contribute substantially to hospitalization among infants, elderly, and immunocompromised. Complete viral clearance from acute infections is not always achieved, leading to persistence. Certain chronic respiratory diseases like asthma and chronic obstructive pulmonary disease have been associated with persistent infection by human respiratory syncytial virus and human rhinovirus, but it is still not clear whether RNA viruses really establish long-term infections as it has been recognized for DNA viruses as human bocavirus and adenoviruses. Herein, we summarize evidence of RNA virus persistence in the human respiratory tract, as well as in some animal models, to highlight how long-term infections might be related to development and/or maintenance of chronic respiratory symptoms.
呼吸道RNA病毒是急性下呼吸道感染的主要病因，在婴儿、老年人和免疫功能低下者中导致大量住院病例。急性感染后并非总能实现病毒的完全清除，从而导致病毒持续存在。某些慢性呼吸道疾病，如哮喘和慢性阻塞性肺疾病，已被认为与人类呼吸道合胞病毒和人鼻病毒的持续感染有关，但RNA病毒是否真的能像人博卡病毒和腺病毒等DNA病毒那样建立长期感染，目前仍不清楚。在此，我们总结了RNA病毒在人类呼吸道以及一些动物模型中持续存在的证据，以强调长期感染可能如何与慢性呼吸道症状的发生和/或维持相关。
