Institute of Structural and Molecular Biology, Birkbeck and UCL, Malet Street, London WC1E 7HX, UK; Current address: MRC Centre for Virus Research, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
Institute of Structural and Molecular Biology, Birkbeck and UCL, Malet Street, London WC1E 7HX, UK.
Trends Microbiol. 2023 Sep;31(9):916-932. doi: 10.1016/j.tim.2023.03.005. Epub 2023 Apr 19.
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting secretion systems or injectisomes. However, prior to secretion, substrates must be recruited to specialized recruitment platforms and then handed over to the secretion apparatus for secretion. In this review, we provide an update on recent advances in substrate recruitment and delivery by gram-negative bacterial recruitment platforms associated with Type III, IV, and VI secretion systems.
细菌利用广泛的大分子底物（DNA 和蛋白质）与原核和真核细胞相互作用或感染细胞。为此，它们利用底物注入分泌系统或注入体。然而，在分泌之前，底物必须被招募到专门的招募平台，然后移交给分泌装置进行分泌。在这篇综述中，我们提供了革兰氏阴性菌与 III 型、IV 型和 VI 型分泌系统相关的招募平台在底物招募和输送方面的最新进展。
