Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.
Department of Neurosurgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
World Neurosurg. 2023 Feb;170:e292-e300. doi: 10.1016/j.wneu.2022.11.008. Epub 2022 Nov 9.
Glioblastoma (GBM) is the most frequently diagnosed malignant brain tumor in adults. GBM is usually lethal within 24 months of diagnosis, despite aggressive multimodality treatment. Although it has been established that cancer-related inflammation is associated with worse outcomes, the role of eosinophils, basophils, atopy, and allergy in glioma biology is only gradually being delineated. In this study, we aimed to examine if eosinophil-based and basophil-based indices were altered in patients with GBM compared with healthy controls. We also aimed to study if there was any correlation between these indices and patient-related and tumor-related factors and survival.
This study was a retrospective analysis of prospectively maintained databases. Data pertaining to patient-related and tumor-related factors, hemograms, and survival data were obtained from the electronic medical records of selected patients. Correlations between eosinophil-based and basophil-based indices and these factors were studied, as was the association with overall survival.
All the indices were altered in patients with GBM compared with normal healthy controls. The absolute eosinophil count was higher and the neutrophils/eosinophils ratio was lower in the better prognosis groups: those with better performance status; those without features of increased intracranial pressure or altered sensorium at presentation; those with ATRX-retained tumors that did not overexpress p53; and in the long-term survivors. The total lymphocyte count/basophils ratio and the absolute eosinophil count both independently predicted survival in a multivariate analysis.
The absolute eosinophil count was consistently higher in the better prognosis groups and is likely to be incorporated into prognostic models for GBM.
胶质母细胞瘤（GBM）是成人中最常见的恶性脑肿瘤。尽管采用了积极的多模式治疗，但 GBM 在诊断后 24 个月内通常仍具有致命性。尽管已经证实癌症相关炎症与较差的预后相关，但嗜酸性粒细胞、嗜碱性粒细胞、特应性和过敏在神经胶质瘤生物学中的作用仍在逐渐被描绘。在这项研究中，我们旨在检查 GBM 患者与健康对照组相比，是否存在基于嗜酸性粒细胞和基于嗜碱性粒细胞的指数改变。我们还旨在研究这些指数与患者相关和肿瘤相关因素与生存之间是否存在相关性。
这是一项对前瞻性维护的数据库进行的回顾性分析。从选定患者的电子病历中获得与患者相关和肿瘤相关因素、血液计数和生存数据。研究了基于嗜酸性粒细胞和基于嗜碱性粒细胞的指数与这些因素之间的相关性，以及与总生存的相关性。
与正常健康对照组相比，所有指数在 GBM 患者中均发生改变。在预后较好的组中，绝对嗜酸性粒细胞计数较高，中性粒细胞/嗜酸性粒细胞比值较低：表现状态较好的患者；无颅内压增高或意识改变特征的患者；ATRX 保留的肿瘤且不表达 p53 的患者；以及长期存活的患者。总淋巴细胞计数/嗜碱性粒细胞比值和绝对嗜酸性粒细胞计数在多变量分析中均独立预测生存。
在预后较好的组中，绝对嗜酸性粒细胞计数始终较高，可能被纳入 GBM 的预后模型。
