Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Gaopeng Street, Keyuan Road 4, Chengdu, 610041, Sichuan, China.
Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Neurosurg Rev. 2021 Dec;44(6):3471-3478. doi: 10.1007/s10143-021-01524-2. Epub 2021 Mar 25.
Accumulating evidence demonstrated that atopic diseases were inversely related to glioma susceptibility and associated with improved prognosis of patients with glioma. This study aimed to elucidate the impacts of basophils, one of the important effector cells in the pathobiology of atopic disease, on prognosis of patients with glioblastoma (GBM). A total of 268 patients were newly diagnosed with GBM and treated with operation at our institution from January 2010 to December 2017. The association between pre-operation circulating eosinophil, basophil, neutrophil, lymphocyte, monocyte count and GBM progression free survival (PFS) was investigated. Moreover, based on the results of multivariate analysis, a prognostic nomogram was established and evaluated. Kaplan-Meier method showed that basophils ≥0.015 × 10/L (p = 0.015) and lymphocytes ≥1.555 × 10/L (p = 0.005) were correlated with better PFS. Cox regression model showed that basophils ≥0.015 × 10/L were an independent prognostic factor for PFS. Prognostic nomogram was established and the concordance index (C-index) for PFS prediction was 0.629. The calibration plots for the probability of 0.5-, 1- and 3-year PFS showed optimal consistency between the prediction by nomogram and actual observation. Increased pre-operation circulating basophils portend better PFS, which might be a useful and novel marker for the prognosis of GBM patients.
越来越多的证据表明，特应性疾病与胶质瘤易感性呈负相关，并与胶质瘤患者的预后改善相关。本研究旨在阐明嗜碱性粒细胞（特应性疾病病理生物学中的一种重要效应细胞）对胶质母细胞瘤（GBM）患者预后的影响。2010 年 1 月至 2017 年 12 月，我院对 268 例新诊断为 GBM 的患者进行了手术治疗。研究了术前循环嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞、淋巴细胞、单核细胞计数与 GBM 无进展生存期（PFS）之间的关系。此外，基于多变量分析的结果，建立并评估了预后列线图。Kaplan-Meier 法显示，嗜碱性粒细胞≥0.015×10/L（p=0.015）和淋巴细胞≥1.555×10/L（p=0.005）与更好的 PFS 相关。Cox 回归模型显示，嗜碱性粒细胞≥0.015×10/L 是 PFS 的独立预后因素。建立了预后列线图，PFS 预测的一致性指数（C-index）为 0.629。0.5 年、1 年和 3 年 PFS 概率的校准图显示，列线图预测与实际观察之间具有最佳一致性。术前循环嗜碱性粒细胞增加预示着更好的 PFS，这可能是预测 GBM 患者预后的一个有用且新颖的标志物。
