Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Division of Rheumatology, Department of Pediatrics, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.
Clin Rheumatol. 2023 Mar;42(3):673-686. doi: 10.1007/s10067-022-06434-2. Epub 2022 Nov 12.
Pediatric primary systemic vasculitides are a complex group of diseases. Vasculitis subgroups are mainly determined according to the size of the predominantly affected vessels. In patients with primary systemic vasculitis, the location of vascular involvement, the size of the vessels, the extent of vascular damage, and the underlying pathology determine the disease phenotype and severity. Cardiac involvement is rare in some pediatric vasculitis, such as IgA vasculitis and polyarteritis nodosa, while it is more common in some others like Kawasaki disease and Takayasu arteritis. On the other hand, chronic inflammation in the setting of systemic vasculitis forms a major cardiovascular risk factor. Accelerated atherosclerosis and the tendency to thrombosis are the main issues determining the cardiovascular risks in pediatric systemic vasculitis. Early diagnosis and treatment are essential in these patients to minimize morbidity and mortality. In this review, we aimed to raise physicians' awareness of cardiac involvement and cardiovascular risks in pediatric patients with primary systemic vasculitis.
儿科原发性系统性血管炎是一组复杂的疾病。血管炎亚组主要根据主要受累血管的大小来确定。在原发性系统性血管炎患者中，血管受累的部位、血管的大小、血管损伤的程度和潜在的病理学决定了疾病表型和严重程度。心脏受累在某些儿科血管炎中较为罕见，如 IgA 血管炎和结节性多动脉炎，而在其他一些疾病中则较为常见，如川崎病和大动脉炎。另一方面，系统性血管炎中的慢性炎症是主要的心血管危险因素。动脉粥样硬化加速和血栓形成倾向是决定儿科系统性血管炎心血管风险的主要问题。早期诊断和治疗对这些患者至关重要，可最大限度地降低发病率和死亡率。在这篇综述中，我们旨在提高医生对儿科原发性系统性血管炎患者心脏受累和心血管风险的认识。
