肾上腺衰老及其对应激反应和免疫衰老的影响。
Adrenal aging and its effects on the stress response and immunosenescence.
机构信息
Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Maturitas. 2023 Feb;168:13-19. doi: 10.1016/j.maturitas.2022.10.006. Epub 2022 Nov 4.
Abstract
Normal aging is linked to various endocrine gland changes, including changes in the adrenal glands. Aging is linked to alterations of the hypothalamic-pituitary-adrenal (HPA) axis, including an increase in cortisol levels, a disruption of the negative cortisol feedback, and attenuation of cortisol's diurnal pattern. In addition, secretion of aldosterone and adrenal androgens [dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)] from the adrenal cortex decreases with aging. In this review, we describe normal adrenal function, the adrenal response to stress and immunomodulation in aging individuals as well as the effects of adrenal aging on body composition, metabolic profile, bone health and cognition.
摘要
正常衰老与各种内分泌腺体变化有关，包括肾上腺的变化。衰老与下丘脑-垂体-肾上腺（HPA）轴的改变有关，包括皮质醇水平升高、皮质醇负反馈中断以及皮质醇昼夜节律减弱。此外，肾上腺皮质分泌的醛固酮和肾上腺雄激素[脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）]随着年龄的增长而减少。在这篇综述中，我们描述了正常的肾上腺功能、衰老个体的肾上腺对应激和免疫调节的反应以及肾上腺衰老对身体成分、代谢特征、骨骼健康和认知的影响。
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