Deltourbe Léa G, Sugrue Jamie, Maloney Elizabeth, Dubois Florian, Jaquaniello Anthony, Bergstedt Jacob, Patin Etienne, Quintana-Murci Lluis, Ingersoll Molly A, Duffy Darragh
Mucosal Inflammation and Immunity Team, Université Paris Cité, CNRS, Inserm, Institut Cochin, Paris 75014, and Department of Immunology, Institut Pasteur, Paris 75015, France.
Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris 75015, France.
Sci Adv. 2025 Mar 28;11(13):eadu6094. doi: 10.1126/sciadv.adu6094.
Steroid hormone levels vary greatly among individuals, between sexes, with age, and across health and disease. What drives variance in steroid hormones and how they vary in individuals over time are not well studied. To address these questions, we measured 17 steroid hormones in a sex-balanced cohort of 949 healthy donors aged 20 to 69 years. We investigated associations between steroid levels and biological sex, age, clinical and demographic data, genetics, and plasma proteomics. Steroid hormone levels were strongly affected by sex and age, and a high number of lifestyle habits. Key observations were the broad impact of hormonal birth control in female donors and the relationship with smoking in male donors. In a 10-year follow-up study, we identified significant associations between steroid hormone levels and health status only in male donors. These observations highlight biological and lifestyle parameters affecting steroid hormones, and underlie the importance of considering sex, age, and potentially gendered behaviors in the treatment of hormone-related diseases.
类固醇激素水平在个体之间、性别之间、随年龄增长以及在健康与疾病状态下差异很大。是什么驱动了类固醇激素的差异以及它们随时间在个体中如何变化尚未得到充分研究。为了解决这些问题，我们在一个由949名年龄在20至69岁之间的健康供体组成的性别均衡队列中测量了17种类固醇激素。我们研究了类固醇水平与生物性别、年龄、临床和人口统计学数据、遗传学以及血浆蛋白质组学之间的关联。类固醇激素水平受到性别、年龄以及大量生活习惯的强烈影响。关键观察结果是激素避孕对女性供体的广泛影响以及男性供体中吸烟与之的关系。在一项为期10年的随访研究中，我们仅在男性供体中发现了类固醇激素水平与健康状况之间的显著关联。这些观察结果突出了影响类固醇激素的生物学和生活方式参数，并强调了在治疗激素相关疾病时考虑性别、年龄以及潜在的性别化行为的重要性。
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