不同唑类药物敏感性表型曲霉菌属临床分离株的分析。
Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles.
机构信息
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Special Mycology Laboratory, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
出版信息
Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0110122. doi: 10.1128/aac.01101-22. Epub 2022 Nov 14.
Abstract
We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of mutations. mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into Saccharomyces cerevisiae susceptible host strain. Transformants were not resistant to either fluconazole nor voriconazole. Our results suggest that variants exist among T. asahii isolates, but are not responsible for resistance phenotypes.
摘要
我们分析了一组具有不同氟康唑和伏立康唑 MIC 的近平滑假丝酵母菌菌株，并评估了突变的存在。发现了一个导致氨基酸改变的突变，并通过克隆到酵母敏感宿主菌株中来评估其耐药潜能。转化体对氟康唑和伏立康唑均无耐药性。我们的结果表明，在近平滑假丝酵母菌分离株中存在 变异体，但它们不是耐药表型的原因。
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