有限的突变被鉴定为直接导致假丝酵母菌属耳念珠菌对唑类药物敏感性降低的原因。
Limited Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility.
机构信息
Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA
Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
出版信息
Antimicrob Agents Chemother. 2018 Sep 24;62(10). doi: 10.1128/AAC.01427-18. Print 2018 Oct.
Abstract
Multiple Erg11 amino acid substitutions were identified in clinical isolates of originating from India and Colombia. Elevated azole MICs were detected in upon heterologous expression of alleles that encoded for Y132F or K143R substitutions; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs. Similar to other species, specific mutations resulted directly in reduced azole susceptibility.
摘要
在来自印度和哥伦比亚的临床分离株中鉴定出多个 Erg11 氨基酸替换。在异源表达编码 Y132F 或 K143R 替换的 等位基因时， 中检测到唑类药物 MIC 值升高；然而，表达编码 I466M、Y501H 或其他谱系定义的氨基酸差异的等位基因导致敏感的 MIC 值。与其他 物种相似，特定的 突变直接导致唑类药物敏感性降低。
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