抗病毒耐药性对疱疹性角膜炎的影响。
The Impact of Antiviral Resistance on Herpetic Keratitis.
作者信息
Moshirfar Majid, Kelkar Neil, Peterson Telyn, Bradshaw Justin, Parker Lawsen, Ronquillo Yasmyne C, Hoopes Phillip C
机构信息
Hoopes Vision Research Center (M.M., Y.C.R., P.C.H.), Hoopes Vision, Draper, UT; John A. Moran Eye Center (M.M.), Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT; Utah Lions Eye Bank (M.M.), Murray, UT; University of Arizona College of Medicine-Phoenix (N.K.), Phoenix, AZ; and Rocky Vista University College of Osteopathic Medicine (T.P., J.B., L.P.), Ivins, UT.
出版信息
Eye Contact Lens. 2023 Mar 1;49(3):127-134. doi: 10.1097/ICL.0000000000000952. Epub 2022 Nov 11.
Herpes simplex keratitis resistance to antiviral treatment presents a growing concern. The herpes simplex virus has many different mechanisms of resistance to antiviral treatment, which have been well described. Resistance to acyclovir occurs because of mutations in the viral thymidylate kinase and DNA polymerase that decrease this enzyme's affinity for its substrate. This article discusses factors that explain the prevalence of this resistance, the ability for recurrences in immunocompromised populations, current treatments for acyclovir-resistant herpes simplex keratitis, and novel therapies for this growing concern.
单纯疱疹性角膜炎对抗病毒治疗的耐药性日益引起关注。单纯疱疹病毒对抗病毒治疗有许多不同的耐药机制，这些机制已得到充分描述。由于病毒胸苷激酶和DNA聚合酶的突变导致对阿昔洛韦耐药，这些突变会降低该酶对其底物的亲和力。本文讨论了解释这种耐药性流行的因素、免疫功能低下人群复发的可能性、目前对阿昔洛韦耐药的单纯疱疹性角膜炎的治疗方法以及针对这一日益严重问题的新疗法。
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