Novel post-translational modifications in the kidneys for human health and diseases.

Short-chain fatty acids (SFCAs) exhibit diverse functions from kidneys to human health and diseases, and also could exert their roles in post-translational modifications (PTMs). Nowadays, novel short-chain lysine acylations derived from SFCAs have attracted more attentions, including propionylation, butyrylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, malonylation, succinylation, crotonylation, glutarylation, lactylation, etc. These acylations have multiple physiological effects on many diseases, which also contribute to kidney pathophysiology. Here, we summarize the role of the currently novel PTMs in the kidneys for human health and diseases.