Kidney Research Institute, Division of Nephrology, West China Hospital Sichuan University, Chengdu 610041, China.
Department of Cardiovascular Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
Life Sci. 2022 Dec 15;311(Pt B):121188. doi: 10.1016/j.lfs.2022.121188. Epub 2022 Nov 12.
Short-chain fatty acids (SFCAs) exhibit diverse functions from kidneys to human health and diseases, and also could exert their roles in post-translational modifications (PTMs). Nowadays, novel short-chain lysine acylations derived from SFCAs have attracted more attentions, including propionylation, butyrylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, malonylation, succinylation, crotonylation, glutarylation, lactylation, etc. These acylations have multiple physiological effects on many diseases, which also contribute to kidney pathophysiology. Here, we summarize the role of the currently novel PTMs in the kidneys for human health and diseases.
短链脂肪酸 (SFCAs) 从肾脏到人类健康和疾病都具有多种功能，并且可以在后翻译修饰 (PTMs) 中发挥作用。如今，源自 SFCAs 的新型短链赖氨酸酰化已引起更多关注，包括丙酰化、丁酰化、2-羟异丁酰化、β-羟丁酰化、琥珀酰化、琥珀酰化、巴豆酰化、戊二酰化、乳酰化等。这些酰化作用对许多疾病具有多种生理作用，也有助于肾脏病理生理学。在这里，我们总结了目前新型 PTMs 在肾脏中对人类健康和疾病的作用。
