This study aimed to compare the effects of Autonomous sensory meridian response (ASMR) and binaural beat (BB) on stress reduction, and to determine whether ASMR and BB can induce changes in quantitative electroencephalography (QEEG). A double-blind randomized trial was conducted. Subjects with stress were recruited considering their perceived stress scale (PSS), Beck depression inventory-II (BDI-II), insomnia severity index (ISI), and state-trait anxiety inventory-state anxiety (STAI-S) scores. Subjects listened to ASMR or BB with music (8 Hz for daytime, 5 Hz for nighttime) for 15 min in daytime and 30 min before going to sleep for 3 weeks. QEEG was measured before and after the intervention. Seventy-six participants (57 female, mean age = 46.12 ± 12.01) finished the trial. After the intervention, PSS, BDI-II, ISI, STAI-S, and PSQI scores improved significantly in both groups. BDI-II and ISI mean scores were normalized in both groups after the intervention. Changes of absolute beta and high beta power in the ASMR group were larger than those in the BB group (p = 0.026, p = 0.040, respectively). Both ASMR and BB are equally effective in reducing stress levels. Unlike BB, ASMR can lead to an increase in beta and high beta waves associated with cortical arousal.