KYIV MEDICAL UNIVERSITY, KYIV, UKRAINE.
UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Wiad Lek. 2022;75(9 pt 2):2218-2221. doi: 10.36740/WLek202209207.
The aim: Analyze the gut microbiome state in patients with migraine (M) and healthy individuals, to assess possible correlations between the detected changes in patients with migraine and the frequency, intensity of headaches, psycho-emotional state of the patients, and their quality of life.
Materials and methods: 100 objects were enrolled, divided into 2 groups: main - patients with M and control - healthy volunteers. Investigation of the intestinal microbiome was performed by chromato-mass spectrometry. For M patients the following scales were used: Visual Analogue Scale (VAS), Migraine Disability Assessment (MIDAS), Back Depression Inventory (BDI).
Results: In main group increased amount of Alcaligenes spp (p = 0.0061), Clostridium coccoides (p = 0.0021), Clostridium propionicum (p = 0.0287), Eggerthella lenta (p = 0.0138), Pseudonocardia spp (p = 0.0210), Rhodococcus spp (p = 0.0164), Candida spp (p = 0.0079), Micromycetes spp (campesterol) (p = 0.0011) were found. Patients with M had a raised amount of Herpes simplex (p = 0.0305) and endotoxin level (p = 0.0459). Differences in gut microorganisms in both groups were significant. In patients with M negative correlations were observed between Alcaligenes spp ammount and BDI score (r = -0.6226, p =0.007), VAS score (r = -0.489, p = 0.046), headache frequency (r = -0.487, p = 0.046); between the levels of Clostridium coccoides and MIDAS score (r =-0.51, p = 0.035), BDI score (r = -0.54, p = 0.025) and positive correlation between Eggerthella lenta level and VAS score (r =0.4830, p=0.049).
Conclusions: Correlations between changes of gut microbiome and M are promising for further research.
分析偏头痛（M）患者和健康个体的肠道微生物组状态，评估偏头痛患者中检测到的变化与头痛频率、强度、患者的心理情绪状态及其生活质量之间的可能相关性。
材料和方法：共纳入 100 例对象，分为 2 组：主要组 - M 患者，对照组 - 健康志愿者。通过色质联用质谱法对肠道微生物组进行了研究。对于 M 患者，使用了以下量表：视觉模拟量表（VAS）、偏头痛残疾评估（MIDAS）、贝克抑郁量表（BDI）。
结果：在主要组中，发现 Alcaligenes spp 的数量增加（p = 0.0061），Clostridium coccoides（p = 0.0021），Clostridium propionicum（p = 0.0287），Eggerthella lenta（p = 0.0138），Pseudonocardia spp（p = 0.0210），Rhodococcus spp（p = 0.0164），Candida spp（p = 0.0079），Micromycetes spp（campesterol）（p = 0.0011）。M 患者的单纯疱疹病毒（p = 0.0305）和内毒素水平（p = 0.0459）升高。两组之间肠道微生物的差异具有统计学意义。在 M 患者中，Alcaligenes spp 数量与 BDI 评分（r = -0.6226，p = 0.007）、VAS 评分（r = -0.489，p = 0.046）、头痛频率（r = -0.487，p = 0.046）呈负相关；Clostridium coccoides 水平与 MIDAS 评分（r = -0.51，p = 0.035）、BDI 评分（r = -0.54，p = 0.025）呈负相关，Eggerthella lenta 水平与 VAS 评分呈正相关（r = 0.4830，p = 0.049）。
结论：肠道微生物组变化与 M 之间的相关性具有进一步研究的前景。
