Ozturk Ali, Bayraktar Nihayet, Bayraktar Mustafa, Ibrahim Bashar, Bozok Taylan, Resat Ceylan Mehmet
Niğde Omer Halisdemir University, Faculty of Medicine, Department of Medical Microbiology, Niğde, Turkey.
Harran University, Faculty of Medicine, Department of Medical Biochemistry, Şanlıurfa, Turkey.
J Med Biochem. 2022 Oct 15;41(4):526-533. doi: 10.5937/jomb0-37514.
Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy.
The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS.
Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001).
These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.
氨基酸在新陈代谢中起重要作用，可能影响与2019冠状病毒病（COVID-19）相关的结果。在我们的研究中，对住院COVID-19患者的氨基酸血清水平进行了评估，以确定一种新的治疗策略。
检测了68名受试者（包括30名对照者（14名男性和16名女性）和38名COVID-19患者（16名男性和22名女性））涵盖43种氨基酸的氨基酸谱。通过液相色谱-串联质谱法（LC-MS/MS）筛选参与者的氨基酸谱。
与对照组相比，患者组27种氨基酸的血清水平升高。α-氨基庚二酸、肌氨酸和羟脯氨酸在对照组中的含量明显高于患者组（p<0.0001）。13种氨基酸在对照组和病例组之间无显著差异（p≥0.05）。对照组和患者组的平均氨基酸值之间存在显著正相关（r=0.937；p<0.0001）。
这些结果清晰呈现了COVID-19患者的氨基酸血清水平情况。对住院COVID-19患者检测的血清氨基酸可以解释疾病期间患者的代谢状态。
