Institute of Experimental Genetics, Helmholtz Center Munich (GmbH), German research Center for environmental Health, Neuherberg D-85764, Germany.
Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Berlin 13125, Germany.
Nucleic Acids Res. 2023 Jan 6;51(D1):D539-D545. doi: 10.1093/nar/gkac1015.
The CORUM database has been providing comprehensive reference information about experimentally characterized, mammalian protein complexes and their associated biological and biomedical properties since 2007. Given that most catalytic and regulatory functions of the cell are carried out by protein complexes, their composition and characterization is of greatest importance in basic and disease biology. The new CORUM 4.0 release encompasses 5204 protein complexes offering the largest and most comprehensive publicly available dataset of manually curated mammalian protein complexes. The CORUM dataset is built from 5299 different genes, representing 26% of the protein coding genes in humans. Complex information from 3354 scientific articles is mainly obtained from human (70%), mouse (16%) and rat (9%) cells and tissues. Recent curation work includes sets of protein complexes, Functional Complex Groups, that offer comprehensive collections of published data in specific biological processes and molecular functions. In addition, a new graphical analysis tool was implemented that displays co-expression data from the subunits of protein complexes. CORUM is freely accessible at http://mips.helmholtz-muenchen.de/corum/.
CORUM 数据库自 2007 年以来一直提供有关实验鉴定的哺乳动物蛋白质复合物及其相关生物学和生物医学特性的综合参考信息。由于细胞的大多数催化和调节功能都是由蛋白质复合物执行的，因此它们的组成和特性在基础和疾病生物学中是最重要的。新的 CORUM 4.0 版本包含 5204 个蛋白质复合物，提供了最大和最全面的公开可用的哺乳动物蛋白质复合物手动整理数据集。CORUM 数据集由 5299 个不同的基因构建而成，代表人类蛋白质编码基因的 26%。来自 3354 篇科学文章的复杂信息主要来自人类（70%）、小鼠（16%）和大鼠（9%）细胞和组织。最近的整理工作包括蛋白质复合物的集合，即功能复合物组，提供特定生物学过程和分子功能的广泛出版数据集合。此外，还实施了一个新的图形分析工具，该工具显示蛋白质复合物亚基的共表达数据。CORUM 可在 http://mips.helmholtz-muenchen.de/corum/ 免费获取。
