Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Medilead, Inc., Tokyo, Japan.
PLoS One. 2022 Nov 16;17(11):e0277600. doi: 10.1371/journal.pone.0277600. eCollection 2022.
To promote health awareness and improve life expectancy in Hirosaki, a Japanese rural area, the Center of Healthy Aging Program (CHAP) was founded in 2013. The most important characteristic of CHAP is a personalized interview just after the checkup to discuss individual results. We evaluated the clinical and economic effects of CHAP by analyzing the cohort data of voluntary participants from annual health checkups since 2005 in the Iwaki district of Hirosaki. We calculated 10-year incidence risk scores for coronary heart diseases (CHDs) and stroke, and compared the risk-score trend before and after the start of CHAP by adjusting other risk factors using multivariate generalized linear regression analyses. We also predicted the 10-year incidences of CHDs and stroke based on the risk scores, for future scenarios of the two conditions, with and without CHAP, and compared them to their treatment costs between scenarios. The number of participants ranged between 808 and 1,167, from 2008 to 2016. The mean age (55 years) and proportion of women (60%) did not significantly change throughout the period. After adjusting for sex, age, outside temperature on the checkup date, the preparation effect of CHAP in 2012, and risk scores in the previous year, the annual increases in risk scores of CHDs and stroke were significant even after CHAP (+0.413, p <0.001; +0.169, p <0.001, respectively), but slightly less compared to before CHAP (+2.638, p <0.001; +1.155, p <0.001, respectively). Assuming the trend continued until 2021, the 10-year incidences of CHDs and stroke have decreases by 22,486 and 9,603, respectively, and treatment costs decreased by JPY 21,973 and 16,056 million, respectively. CHAP contributes to a significant decrease in the incidences of CHDs and stroke, and reduces economic burden on the local government.
为了提高日本偏远农村弘前市的健康意识并延长预期寿命,健康老龄化中心(CHAP)于 2013 年成立。CHAP 的最重要特征是在体检后进行个性化访谈,以讨论个人体检结果。我们分析了 2005 年以来弘前市岩木地区年度健康检查中自愿参与者的队列数据,评估了 CHAP 的临床和经济效益。我们计算了冠心病(CHD)和中风的 10 年发病风险评分,并通过使用多变量广义线性回归分析调整其他风险因素,比较了 CHAP 启动前后风险评分趋势。我们还根据风险评分预测了 CHD 和中风的 10 年发病率,为没有和有 CHAP 的两种情况的未来情景,并比较了它们之间的治疗费用。参与者人数从 2008 年到 2016 年在 808 至 1167 人之间波动。在此期间,参与者的平均年龄(55 岁)和女性比例(60%)没有显著变化。在调整了性别、年龄、体检日的室外温度、2012 年 CHAP 的准备效果以及前一年的风险评分后,CHD 和中风风险评分的年增长率在 CHAP 之后仍然显著(分别为+0.413,p<0.001;+0.169,p<0.001),但与 CHAP 之前相比略有减少(分别为+2.638,p<0.001;+1.155,p<0.001)。假设这种趋势持续到 2021 年,CHD 和中风的 10 年发病率将分别下降 22486 和 9603 例,治疗费用将分别下降 219.73 和 160.56 亿日元。CHAP 有助于显著降低 CHD 和中风的发病率,并减轻地方政府的经济负担。