Bedard-Gilligan Michele, Lehinger Elizabeth, Cornell-Maier Sarah, Holloway Ash, Zoellner Lori
Department of Psychiatry and Behavioral Sciences, University of Washington.
Department of Psychology, University of Washington.
Curr Addict Rep. 2022 Sep;9(3):203-216. doi: 10.1007/s40429-022-00414-x. Epub 2022 Jun 15.
Individuals with posttraumatic stress disorder (PTSD) may use cannabis to reduce symptoms yet are also at risk for developing problematic use. This review outlines theories, summarizes recent empirical studies, and discusses clinical implications of cannabis use and PTSD recovery.
Although naturalistic studies and open trials find a relationship between cannabinoids and PTSD symptom reduction, methodological limitations preclude definitive conclusions. The only randomized controlled trial to date found cannabis had no greater effect on PTSD symptoms than placebo.
Rigorous studies of the long-term impact of cannabis use on PTSD recovery are needed. Clinicians and researchers must weigh the potential therapeutic effect against the costs and risks associated with long-term cannabis use. Clinicians should consider all available PTSD treatment options, along with client level factors such as the function of cannabis use, motivation to change use, and the potential impact of cannabis on treatment engagement when making clinical recommendations.
创伤后应激障碍（PTSD）患者可能会使用大麻来减轻症状，但同时也有发展为问题性使用的风险。本综述概述了相关理论，总结了近期的实证研究，并讨论了大麻使用与PTSD康复的临床意义。
尽管自然主义研究和开放试验发现大麻素与PTSD症状减轻之间存在关联，但方法学上的局限性妨碍了得出明确结论。迄今为止唯一的一项随机对照试验发现，大麻对PTSD症状的影响并不比安慰剂更大。
需要对大麻使用对PTSD康复的长期影响进行严格研究。临床医生和研究人员必须权衡潜在的治疗效果与长期使用大麻相关的成本和风险。临床医生在提出临床建议时，应考虑所有可用的PTSD治疗方案，以及患者层面的因素，如大麻使用的功能、改变使用的动机以及大麻对治疗参与度的潜在影响。
