Chandran Sruthi, Simon Sheena Ann, George Anuja Elizabeth
Department of Dermatology, Venereology and Leprosy, Government Medical College, Trivandrum, Kerala, India.
Indian J Dermatol. 2022 May-Jun;67(3):216-221. doi: 10.4103/ijd.IJD_642_20.
Greying of hair is a regular feature of chronological aging that occurs in all regions and races. Premature canities is defined as minimum of five grey hairs in a person less than 20 years in Whites, 25 years in Asians, and 30 years in Africans. Premature canities is a common yet incompletely understood dermatological entity. This study aims at finding any association between premature hair greying (PHG) and parameters like hemoglobin (Hb), ferritin and calcium levels as well as its clinical profile.
This was a hospital-based cross-sectional analytical study conducted in the Department of Dermatology and Venereology, Trivandrum over one and half years. The study population consisted of 40 cases and 40 controls. Severity assessment, calculation of body mass index, and estimation of hemoglobin, serum ferritin, calcium, Random blood sugar, Anti Thyroid Peroxidase antibody, T3, T4, and TSH were done.
The mean age of the 40 patients was 17.14 years and most patients had onset of greying between 16 and 20 years. The male to female ratio was 1.2:1. A positive family history with a paternal predominance was noted. Vertex was the most common site of onset (42.5%), diffuse pattern was the most common clinical pattern (47.5%) and 60% had involvement of mild grade. Fourteen patients (35%) had abnormal investigations reports, in terms of low ferritin levels in 7 (17.5%), low calcium in 4 (10%) and a low Hb levels in 3 (7.5%) patients. Six (15%) patients had raised Anti TPO values. The association of PHG with low ferritin and raised anti-TPO levels were statistically significant.
Low serum ferritin and raised Anti TPO levels may have a role in premature hair greying.
头发变白是按时间顺序衰老的一个常见特征，在所有地区和种族中都会出现。早老性白发的定义为：白人中年龄小于20岁、亚洲人年龄小于25岁、非洲人年龄小于30岁的个体，头发至少有五根变白。早老性白发是一种常见但尚未完全了解的皮肤病症。本研究旨在探寻早发性白发（PHG）与血红蛋白（Hb）、铁蛋白、钙水平等参数及其临床特征之间的关联。
这是一项在特里凡得琅皮肤病与性病科进行的为期一年半的基于医院的横断面分析研究。研究对象包括40例病例和40例对照。进行了严重程度评估、体重指数计算以及血红蛋白、血清铁蛋白、钙、随机血糖、抗甲状腺过氧化物酶抗体、T3、T4和促甲状腺激素的测定。
40例患者的平均年龄为17.14岁，大多数患者在16至20岁之间开始出现白发。男女比例为1.2:1。有阳性家族史，且以父系为主。头顶是最常见的发病部位（42.5%），弥漫型是最常见的临床类型（47.5%），60%的患者病情为轻度。14例患者（35%）的检查报告异常，其中7例（17.5%）铁蛋白水平低，4例（10%）钙水平低，3例（7.5%）血红蛋白水平低。6例（15%）患者抗TPO值升高。PHG与低铁蛋白和抗TPO水平升高之间的关联具有统计学意义。
低血清铁蛋白和抗TPO水平升高可能与早发性白发有关。
