Huang Conggai, Zhao Qi, Zhou Xiaoqing, Huang Ran, Duan Yi, Haybaeck Johannes, Yang Zhihui
Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Pathology, Basic Medical College of Southwest Medical University, Luzhou, China.
Front Oncol. 2022 Oct 31;12:898966. doi: 10.3389/fonc.2022.898966. eCollection 2022.
Colorectal diseases are threatening human health, especially inflammatory bowel disease (IBD) and colorectal cancer (CRC). IBD is a group of chronic, recurrent and incurable disease, which may affect the entire gastrointestinal tract, increasing the risk of CRC. Eukaryotic gene expression is a complicated process, which is mainly regulated at the level of gene transcription and mRNA translation. Protein translation in tissue is associated with a sequence of steps, including initiation, elongation, termination and recycling. Abnormal regulation of gene expression is the key to the pathogenesis of CRC. In the early stages of cancer, it is vital to identify new diagnostic and therapeutic targets and biomarkers. This review presented current knowledge on aberrant expression of eIFs, eEFs and eRFs in colorectal diseases. The current findings of protein synthesis on colorectal pathogenesis showed that eIFs, eEFs and eRFs may be potential targets for CRC treatment.
结直肠疾病威胁着人类健康，尤其是炎症性肠病（IBD）和结直肠癌（CRC）。IBD是一组慢性、复发性且无法治愈的疾病，可能会影响整个胃肠道，增加患CRC的风险。真核基因表达是一个复杂的过程，主要在基因转录和mRNA翻译水平上受到调控。组织中的蛋白质翻译与一系列步骤相关，包括起始、延伸、终止和循环利用。基因表达的异常调控是CRC发病机制的关键。在癌症早期，识别新的诊断和治疗靶点以及生物标志物至关重要。本综述介绍了目前关于结直肠疾病中真核起始因子（eIFs）、真核延伸因子（eEFs）和真核释放因子（eRFs）异常表达的知识。目前关于蛋白质合成在结直肠癌发病机制方面的研究结果表明，eIFs、eEFs和eRFs可能是CRC治疗的潜在靶点。
