Hankel Julia, Sander Saara, Muthukumarasamy Uthayakumar, Strowig Till, Kamphues Josef, Jung Klaus, Visscher Christian
Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.
Helmholtz Center for Infection Research, Brunswick, Germany.
Front Vet Sci. 2022 Oct 27;9:1004506. doi: 10.3389/fvets.2022.1004506. eCollection 2022.
(.) is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed -positive pigs under standardized conditions. To obtain three independent repetitions, 27 infected pigs (19.0 ± 1.50 kg body weight) from one farm were divided into three groups at an age of 7 to 8 weeks (nine pigs/group). Pigs were either vaccinated against via oral drenching on their 21st day of life (attenuated live vaccine) or non-vaccinated and selected according to clinical findings (pigs without deviating fecal consistency or with moderate to soft fecal consistency). Comparison of the clinically inconspicuous piglets that differed regarding their vaccination status showed fewer significant differences in fecal microbiota composition. The vaccination led to an overall enrichment of bacterial species belonging to the order , while species of the genus and were decreased. Several bacterial species belonging to the order , mainly of the family , often closely matching differed significantly between non-vaccinated clinically inconspicuous and conspicuous piglets. Whether those bacterial species play a role in mitigating the severity of an infection remains to be defined.
（某细菌名称）是一种广泛存在、具有经济重要性的细菌，可引发猪增生性肠炎（PPE）。在本研究中，我们在标准化条件下评估了自然感染呈阳性的猪的肠道微生物群。为获得三个独立重复样本，从一个猪场选取27头感染猪（体重19.0±1.50千克），在7至8周龄时分为三组（每组9头猪）。这些猪要么在出生第21天通过口服灌服进行针对（某细菌名称）的疫苗接种（减毒活疫苗），要么未接种疫苗，并根据临床症状进行挑选（粪便质地无异常或粪便质地为中度至柔软的猪）。对临床症状不明显但疫苗接种状态不同的仔猪进行比较发现，粪便微生物群组成方面的显著差异较少。疫苗接种导致属于（某细菌目名称）的细菌种类总体富集，而（某细菌属名称）和（另一细菌属名称）的种类减少。在未接种疫苗的临床症状不明显和明显的仔猪之间，属于（某细菌目名称）的几种细菌种类，主要是（某细菌科名称）的种类，通常与（某细菌名称）密切匹配，存在显著差异。这些细菌种类是否在减轻（某细菌名称）感染的严重程度中发挥作用仍有待确定。
