Meschede J, Holtrup S, Deitmer R, Mesu A P, Kraft C
Vivet Schweinegesundheit GmbH, Kahrweg 33, 59590 Geseke, Germany.
Boehringer Ingelheim Vetmedica GmbH, Binger Str. 173, 55216 Ingelheim, Germany.
Heliyon. 2021 Apr 14;7(4):e06714. doi: 10.1016/j.heliyon.2021.e06714. eCollection 2021 Apr.
spp. remains a wide-spread pathogen among pig herds and its control has major impact on food borne infections in humans. The objective of the study was to investigate the influence of an Enterisol® Ileitis vaccination on seroprevalence in () and spp. co-infected pig herds under field conditions. This study compared vaccinated and non-vaccinated pigs of consecutive piglet batches, housed on four different finishing units. Prior to study start, endemic field infections of and spp. were confirmed by serology in the nursery and in all finishing units. Field infection of occurred at the middle of the nursery phase. In total twenty-five batches of finishing pigs were included in the study, pigs were investigated for four (non-vaccinated group, n = 9) or six months (vaccinated group, n = 16). The primary outcome parameter was serology (antibody titers) at the end of fattening. Secondary parameters comprised serology for and performance parameters, including average daily weight gain (g), duration of fattening period (days), feed conversion (kg/kg) and mortality (%). A total of 709 blood samples were assessed, deriving from vaccinated (n = 439) and non-vaccinated finishing pigs (n = 270). Evaluation of the antibody titers demonstrated that vaccination significantly reduced the seroprevalence in the finishing pigs on all four farms. The average OD% values were reduced from 32.7% to 13.4% in addition to a reduced variability in the vaccinated pigs compared to the control group. The category of all finishing farms improved by at least one category in accordance with the German monitoring program. In addition, vaccination had a positive tendency on the average daily weight gain, fattening duration and reduced mortality. In conclusion, this study demonstrates that vaccination with Enterisol® Ileitis has a positive and direct impact on reduction of infection in co-infected herds.
某菌属仍然是猪群中广泛传播的病原体，对其进行防控对人类食源性感染有重大影响。本研究的目的是调查在田间条件下，肠内梭菌性回肠炎疫苗对某菌属和另一菌属共同感染猪群血清阳性率的影响。本研究比较了连续仔猪批次中接种疫苗和未接种疫苗的猪，这些猪饲养在四个不同的育肥单元。在研究开始前，通过血清学在保育舍和所有育肥单元确认了某菌属和另一菌属的地方性田间感染。某菌属的田间感染发生在保育期中期。本研究共纳入了25批育肥猪，对猪进行了4个月（未接种疫苗组，n = 9）或6个月（接种疫苗组，n = 16）的调查。主要结局参数是育肥结束时某菌属的血清学（抗体滴度）。次要参数包括另一菌属的血清学和生产性能参数，包括平均日增重（克）、育肥期持续时间（天）、饲料转化率（千克/千克）和死亡率（%）。共评估了709份血样，分别来自接种疫苗的育肥猪（n = 439）和未接种疫苗的育肥猪（n = 270）。抗体滴度评估表明，疫苗接种显著降低了所有四个农场育肥猪中某菌属的血清阳性率。与对照组相比，接种疫苗的猪的平均OD%值从32.7%降至13.4%，且变异性降低。根据德国某监测计划，所有育肥农场的某菌属类别至少提高了一个类别。此外，疫苗接种对平均日增重、育肥持续时间和降低死亡率有积极趋势。总之，本研究表明，使用肠内梭菌性回肠炎疫苗接种对减少共同感染猪群中的某菌属感染有积极且直接的影响。
