Padhye Mugdha R, Yadav Nikhil S
Department of Pharmacology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, India.
J Family Med Prim Care. 2022 Jul;11(7):3726-3729. doi: 10.4103/jfmpc.jfmpc_2205_21. Epub 2022 Jul 22.
Hyperlipidemia plays a major role in the pathogenesis of cardiovascular diseases (CVD). Statins are considered to be the most efficacious drugs in the management of hyperlipidemia and this class of drugs is most commonly prescribed for the treatment of hyperlipidemias. Although statin therapy has transformed the management of hyperlipidemia, it is associated with the skeletal muscle, neurological, and metabolic adverse effects. This study was conducted to evaluate the adverse effects of statin therapy in a geriatric population which may help in understanding whether these effects are dose-dependent.
The study was conducted on 200 patients receiving statin therapy (atorvastatin and rosuvastatin) for hyperlipidemias. They were divided into four groups depending on the prescribed dose of atorvastatin and rosuvastatin. All study subjects were followed up for 6 months. The adverse effects reported by them during the statin therapy were documented and analyzed.
All patients reported adverse effects after the initiation of statin therapy. Headache and muscle symptoms were among the most commonly reported adverse effects. There was no serious adverse effect (SAE). None of the adverse effects led to the discontinuation of the statin therapy.
The results of this study suggest that all patients receiving statin therapy experience one or more adverse effects during the therapy. The adverse effects were not found to be severe in the geriatric age group.
高脂血症在心血管疾病（CVD）的发病机制中起主要作用。他汀类药物被认为是治疗高脂血症最有效的药物，这类药物是治疗高脂血症最常用的处方药。尽管他汀类药物治疗已经改变了高脂血症的管理方式，但它与骨骼肌、神经和代谢方面的不良反应有关。本研究旨在评估他汀类药物治疗在老年人群中的不良反应，这可能有助于了解这些不良反应是否与剂量有关。
本研究对200例接受他汀类药物（阿托伐他汀和瑞舒伐他汀）治疗高脂血症的患者进行。根据阿托伐他汀和瑞舒伐他汀的规定剂量将他们分为四组。所有研究对象随访6个月。记录并分析他们在他汀类药物治疗期间报告的不良反应。
所有患者在开始他汀类药物治疗后均报告有不良反应。头痛和肌肉症状是最常报告的不良反应。没有严重不良反应（SAE）。没有一种不良反应导致他汀类药物治疗中断。
本研究结果表明，所有接受他汀类药物治疗的患者在治疗期间都会经历一种或多种不良反应。在老年年龄组中，不良反应并不严重。
