Petrella Francesco, Rizzo Stefania, Casiraghi Monica, Bardoni Claudia, Mohamed Shehab, Musso Valeria, Simonini Emanuele, Spaggiari Lorenzo
Department of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Transl Cancer Res. 2022 Oct;11(10):3869-3875. doi: 10.21037/tcr-22-1491.
Lung cancer is the leading cause of cancer-related deaths worldwide, and its incidence has increased over the past two decades. The standard care for stage I, stage II, and selected cases of stage IIIA non-small cell lung cancer (NSCLC) is surgical resection; in some cases, patients may be offered adjuvant systemic therapy after surgical resection. Patients with lung cancer presenting with distant metastases belong to stage IV: in this setting, some carefully selected patients may benefit from surgery within a multimodality approach.
We performed a comprehensive, non-systematic review of the latest literature to define the present role of surgery in lung cancer treatment.
The literature review disclosed a pivotal role of surgery in early stage lung cancer and a complimentary role in locally advanced lung cancer; in very selected cases, surgery might be considered in oligometastatic disease.
Surgical treatment of lung cancer still plays a pivotal role in early stages of the disease while, in locally advanced stages, it may contribute to improve overall survival in combination with medical treatments and radiotherapy. More recently, an effective role of surgery has been advocated in carefully selected oligometastatic patients with encouraging initial results.
肺癌是全球癌症相关死亡的主要原因，且在过去二十年中其发病率有所上升。I期、II期以及部分IIIA期非小细胞肺癌（NSCLC）的标准治疗方法是手术切除；在某些情况下，患者术后可能会接受辅助全身治疗。出现远处转移的肺癌患者属于IV期：在此情况下，一些经过精心挑选的患者可能会在多学科综合治疗中受益于手术。
我们对最新文献进行了全面的非系统性综述，以确定目前手术在肺癌治疗中的作用。
文献综述揭示了手术在早期肺癌中的关键作用以及在局部晚期肺癌中的辅助作用；在极少数特定情况下，寡转移疾病患者可考虑手术治疗。
肺癌的手术治疗在疾病早期仍起着关键作用，而在局部晚期，与药物治疗和放疗联合使用时，手术可能有助于提高总生存率。最近，对于经过精心挑选的寡转移患者，手术的有效作用得到了提倡，初步结果令人鼓舞。
