Pollard Rebecca, Chen Pei Jung, Mackes Nuria, Lawrence Andrew J, Ma Xuemei, Matter Maryam, Kretzer Svenja, Morgan Craig, Harding Seeromanie, Schumann Gunter, Pariante Carmine, Mehta Mitul, Montana Giovanni, Nosarti Chiara, Desrivieres Sylvane, Rodriguez-Mateos Ana, Dazzan Paola
Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Brain Behav Immun Health. 2022 Oct 28;26:100539. doi: 10.1016/j.bbih.2022.100539. eCollection 2022 Dec.
More than 1 in 10 people are thought to experience a mental health problem during adolescence, with most adult psychopathology beginning during this time. Experiences of stress or adversity during childhood are important risk factors for poorer mental health outcomes and are also associated with alterations in neurodevelopment. There is evidence to suggest that this relationship is mediated by inflammation and the immune system. The eBRAIN study (The Impact of Early Adversity on Trajectories of Brain Maturation and Mental Health in Young Adolescents) will assess how early life adversity might affect trajectories of brain development throughout adolescence, whether these neurobiological changes are associated with psychopathology, and if they can potentially be explained by an activation of the immune system.
A cohort of 220 adolescents between the ages of 11-14 will be recruited into this study. Each participant will complete three study visits, each one year apart, at the Institute of Psychiatry, Psychology and Neuroscience, King's College London, London (UK). At each study visit, they will be assessed with structural and functional MRI scans, biological sample collection as well as questionnaires and interviews to collect demographic information, assess experiences of adversity, and details of psychopathology. The study will also collect information about factors such as diet and nutrition, physical exercise, and cognition.
Ethical approval for this study has been received by King's College London Research Ethics Committee (REC reference: HR-18/19-9033). Findings from the study will be published in peer-reviewed journals and disseminated at national and international conferences. Patient and public involvement (PPI) is an important component of the study, 'Study Champions' recruited from participants, their parents and teachers at collaborating schools have been invited to take an active role in study governance and dissemination.
据认为，超过十分之一的人在青春期会经历心理健康问题，大多数成人精神病理学问题都始于这个时期。童年时期的压力或逆境经历是心理健康状况较差的重要风险因素，也与神经发育改变有关。有证据表明，这种关系是由炎症和免疫系统介导的。eBRAIN研究（早期逆境对青少年脑成熟轨迹和心理健康的影响）将评估早期生活逆境如何影响整个青春期的脑发育轨迹，这些神经生物学变化是否与精神病理学有关，以及它们是否可能由免疫系统的激活来解释。
将招募220名年龄在11至14岁之间的青少年组成队列参与本研究。每位参与者将在英国伦敦国王学院精神病学、心理学和神经科学研究所进行三次研究访视，每次访视间隔一年。在每次研究访视时，他们将接受结构和功能磁共振成像扫描、生物样本采集，以及问卷调查和访谈，以收集人口统计学信息、评估逆境经历和精神病理学细节。该研究还将收集有关饮食和营养、体育锻炼和认知等因素的信息。
本研究已获得伦敦国王学院研究伦理委员会的伦理批准（伦理委员会参考号：HR-18/19-9033）。研究结果将发表在同行评审期刊上，并在国内和国际会议上传播。患者和公众参与（PPI）是该研究的重要组成部分，已邀请从参与者、他们的父母以及合作学校的教师中招募的“研究倡导者”在研究管理和传播中发挥积极作用。
