Gollier-Briant Fanny, Paillère-Martinot Marie-Laure, Lemaitre Hervé, Miranda Ruben, Vulser Hélène, Goodman Robert, Penttilä Jani, Struve Maren, Fadai Tahmine, Kappel Viola, Poustka Luise, Grimmer Yvonne, Bromberg Uli, Conrod Patricia, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Büchel Christian, Flor Herta, Gallinat Juergen, Garavan Hugh, Heinz Andreas, Lawrence Claire, Mann Karl, Nees Frauke, Paus Tomas, Pausova Zdenka, Frouin Vincent, Rietschel Marcella, Robbins Trevor W, Smolka Michael N, Schumann Gunter, Martinot Jean-Luc, Artiges Eric
INSERM, UMR 1000, Research Unit NeuroImaging and Psychiatry, Service Hospitalier Frédéric Joliot, Orsay, University Paris-Sud, University Paris Saclay, Orsay, and Maison De Solenn, University Paris Descartes, Paris, France.
AP-HP, Department of Adolescent Psychopathology and Medicine, Maison De Solenn, Cochin Hospital, Paris, France.
Soc Cogn Affect Neurosci. 2016 Dec;11(12):1961-1969. doi: 10.1093/scan/nsw100. Epub 2016 Oct 3.
Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate to NLE in the frontal-limbic emotional regions. Participants (N = 685) were drawn from the Imagen database of 14-year-old community adolescents recruited in schools. They underwent functional MRI while viewing angry and neutral faces, as a probe to neural response to social threat. Lifetime NLEs were assessed using the 'distress', 'family' and 'accident' subscales from a life event dimensional questionnaire. Relationships between NLE subscale scores and neural response were investigated. Links of NLE subscales scores with anxiety or depression outcomes at the age of 16 years were also investigated. Lifetime 'distress' positively correlated with ventral-lateral orbitofrontal and temporal cortex activations during angry face processing. 'Distress' scores correlated with the probabilities of meeting criteria for Generalized Anxiety Disorder or Major Depressive Disorder at the age of 16 years. Lifetime 'family' and 'accident' scores did not relate with neural response or follow-up conditions, however. Thus, different types of NLEs differentially predicted neural responses to threat during adolescence, and differentially predicted a de novo internalizing condition 2 years later. The deleterious effect of self-referential NLEs is suggested.
消极生活事件（NLE）会导致焦虑和抑郁障碍，但它们与青少年大脑功能之间的关系鲜有研究。我们假设，大脑对社会威胁的神经反应与额叶-边缘情绪区域的消极生活事件有关。参与者（N = 685）来自在学校招募的14岁社区青少年的Imagen数据库。他们在观看愤怒和中性面孔时接受功能磁共振成像，以此作为对社会威胁的神经反应的探测。使用生活事件维度问卷中的“痛苦”“家庭”和“事故”分量表来评估终生消极生活事件。研究了消极生活事件分量表得分与神经反应之间的关系。还研究了消极生活事件分量表得分与16岁时焦虑或抑郁结果之间的联系。终生“痛苦”与愤怒面孔加工过程中腹侧外侧眶额皮质和颞叶皮质的激活呈正相关。“痛苦”得分与16岁时符合广泛性焦虑障碍或重度抑郁症标准的概率相关。然而，终生“家庭”和“事故”得分与神经反应或随访情况无关。因此，不同类型的消极生活事件在青少年时期对威胁的神经反应有不同的预测作用，并且对两年后的新发内化状况也有不同的预测作用。这表明了自我参照性消极生活事件的有害影响。
