Li Shaojun, Wei Jiana, Huang Ruiyun, Li Chenghao, Chen Hongbing, Qiu Zhihua, Jiang Yongjun, Wu Li
Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Front Neurol. 2022 Oct 28;13:1019036. doi: 10.3389/fneur.2022.1019036. eCollection 2022.
High-resolution magnetic resonance imaging (HR-MRI) is used to characterize atherosclerotic plaque. The present study aimed to determine the high-risk features of the basilar artery (BA) atherosclerotic plaque.
Patients with advanced BA stenosis were screened. The features including the ruptured fibrous cap (RFC), lipid core, intraplaque hemorrhage (IPH), plaque enhancement, and calcification were assessed by using high-resolution MRI. The relationship between the features and acute infarction was analyzed.
From 1 June 2014 to 31 December 2018, a total of 143 patients with 76 new strokes were included. RFC was identified in 25% of symptomatic and 10.4% of asymptomatic patients. IPH was identified in 48.7% of symptomatic and 25.4% of asymptomatic patients. RFC (3.157, 95% CI 1.062 to 9.382, = 0.039) and IPH (2.78, 95% CI 1.127 to 6.505, = 0.026) were independent risk factors for acute infarction.
Our study showed that RFC and IPH of BA plaque were independent risk factors for acute infarction.
高分辨率磁共振成像（HR-MRI）用于表征动脉粥样硬化斑块。本研究旨在确定基底动脉（BA）粥样硬化斑块的高危特征。
筛选患有晚期BA狭窄的患者。使用高分辨率MRI评估包括纤维帽破裂（RFC）、脂质核心、斑块内出血（IPH）、斑块强化和钙化等特征。分析这些特征与急性梗死之间的关系。
2014年6月1日至2018年12月31日，共纳入143例患者，其中76例发生新的卒中。有症状患者中25%发现RFC，无症状患者中10.4%发现RFC。有症状患者中48.7%发现IPH，无症状患者中25.4%发现IPH。RFC（3.157，95%可信区间1.062至9.382，P = 0.039）和IPH（2.78，95%可信区间1.127至6.505，P = 0.026）是急性梗死的独立危险因素。
我们的研究表明，BA斑块的RFC和IPH是急性梗死的独立危险因素。
